199742-37-5Relevant academic research and scientific papers
Direct catalytic asymmetric three-component Kabachnik-fields reaction
Cheng, Xu,Goddard, Richard,Buth, Gernot,List, Benjamin
, p. 5079 - 5081 (2008)
(Chemical Equation Presented) As mimics of α-amino acids, α-amino phosphonates have great promise as antibacterial and anti-HIV agents as well as protease inhibitors. Racemic α-branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p-anisidine (PMPNH2) and a phosphite to furnish β-branched α-amino phosphonates highly diastereoselectively and enantioselectively. Anth = anthracenyl.
