199784-56-0Relevant articles and documents
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-Aryloxy substituents of 2,6-diphenoxypyridines
Ng, Howard P.,Buckman, Brad O.,Eagen, Keith A.,Guilford, William J.,Kochanny, Monica J.,Mohan, Raju,Shaw, Kenneth J.,Wu, Shung C.,Lentz, Dao,Liang, Amy,Trinh, Lan,Ho, Elena,Smith, David,Subramanyam, Babu,Vergona, Ron,Walters, Janette,White, Kathy A.,Sullivan, Mark E.,Morrissey, Michael M.,Phillips, Gary B.
, p. 657 - 666 (2002)
A novel series of triaryloxypyridines have been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. Inhibitor 5e has a KI against factor Xa of 0.12 nM and is greater than 8000- and 2000-fold select
Benzamidine derivatives and their use as anti-coagulants
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, (2008/06/13)
This invention is directed to benzamidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat disease-states characterized by thrombotic activity.