199794-20-2Relevant academic research and scientific papers
Stereocontrolled Syntheses of Deoxyribonucleosides via Photoinduced Electron-Transfer Deoxygenation of Benzoyl-Protected Ribo- and Arabinonucleosides
Wang, Zhiwei,Prudhomme, Daniel R.,Buck, Jason R.,Park, Minnie,Rizzo, Carmelo J.
, p. 5969 - 5985 (2007/10/03)
The stereocontrolled, de novo syntheses of β-2′-deoxy-, α-2′-deoxy-, β-3′-deoxy-, and β-2′,3′-dideoxyribonucleosides are described. Strategically protected ribose, arabinose, and xylose glycosylation precursors were synthesized bearing C2-esters capable of directing Vorbrueggen glycosylation. The key step is the regioselective deoxygenation of the desired hydroxyl group as either the benzoyl- or 3-(trifluoromethyl)benzoyl derivative. This deoxygenation is accomplished via a photoinduced electron-transfer (PET) mechanism using carbazole derivatives as the photosensitizer. The syntheses of the desired deoxynucleoside generally proceed in three steps from a common, readily available precursor.
Stereocontrolled synthesis of α-2'-deoxyribonucleosides
Wang, Zhiwei,Rizzo, Carmelo J.
, p. 8177 - 8180 (2007/10/03)
A stereocontrolled synthesis of α-2'-deoxynucleosides has been achieved. Our synthetic strategy involves the use of a benzoyl group at the 2-position of arabinose as a directing group for Vorbruggen glycosylation and a deoxygenation precursor.
