199800-46-9

Upstream product

• 108310-92-5 2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate 
• 86137-72-6 2'-deoxy-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 

Downstream Products

• 199800-59-4 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-O⁶-<2-(4-nitrophenyl)ethyl>-N²-phthaloylguanosine 
• 226894-56-0 (2R,3S,5R)-5-{2-Amino-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-ol 
• 81144-43-6 5'-O-(p,p'-dimethoxytrityl)-2'-deoxyguanosine 

Relevant academic research and scientific papers

Nucleotides: Part LXI: Phthaloyl strategy: A new concept of oligonucleotide synthesis

A new alternative strategy of oligonucleotide synthesis was developed by use of the phthaloyl protecting group for the exocyclic amino functions of the nucleobases (see 9-12). This approach combines the advantages of cheap and easily accessible monomeric building blocks (see 17- 20), standard machine-aided oligonucleotide synthesis, and a fast deprotection protocol which is orthogonal to the cleavage procedure from the solid support. The crude oligonucleotides show high purity and require, in general, no further chromatographic purification.