199806-33-2

Basic information

• Product Name: 5-(Acetamido)-N-[2-[1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-ylcarbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide
• CAS NO: 199806-33-2
• Molecular Formula: C₃₃H₂₆ClN₅O₄
• Molecular Weight: 592.05927
• Mol File: 199806-33-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(Acetamido)-N-[2-[1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-ylcarbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Acetamido)-N-[2-[1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-ylcarbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide(199806-33-2)
• EPA Substance Registry System: 5-(Acetamido)-N-[2-[1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-ylcarbonyl]-1H-indol-5-yl]-1H-indole-2-carboxamide(199806-33-2)

Safety Data

• Hazardous Substances Data: 199806-33-2(Hazardous Substances Data)

Upstream product

• 199805-81-7 5-[(5-acetylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carboxylic acid ethyl ester 
• 199805-80-6 5-(acetylamino)indole-2-carboxylic acid 
• 110887-42-8 ethyl 5-acetamido-1H-indole-2-carboxylate 
• 122745-46-4 1,2,9,9a-tetrahydrocyclopropa[e]benz[e]indol-4-one 
• 16732-57-3 5-nitro-indole-2-carboxylic acid ethyl ester 
• 71086-99-2 ethyl 5-amino-1H-indole-2-carboxylate 
• 199805-82-8 5-[(5-acetamido-1H-indol-2-ylcarbonyl)amino]-1H-indole-2-carboxylic acid 
• 122745-42-0 1-Chloromethyl-2,3-dihydro-1H-benzo[e]indol-5-ol; hydrochloride 

Relevant articles and documents

CC-1065 analogues bearing different DNA-binding subunits: Synthesis, antitumor activity, and preliminary toxicity study

CC-1065 analogues bearing different DNA-binding subunits were synthesized. A terminal C5-NO2 and -F moiety at the DNA-binding subunit increased the drug's potency and antitumor efficacy. A C5-OCH3 reduced the potency and antitumor efficacy. Compound (±)-7, bearing a trans double bond, had increased antitumor efficacy. A preliminary toxicity study indicated that terminal C5-OCH3 and -acetamido moieties at the DNA-binding subunit caused delayed death in mice.

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The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy dihydrobenzindole oligopeptides and prodrugs thereof wherein the monomeric constituents are derived from monocyclic or bicyclic heterocyclic aromatic residues.