19983-42-7

Usage

Uses

Used in Pharmaceutical Industry:
6-Nitrobenzo[b]thiophene-2-carboxylic acid is used as an intermediate in the synthesis of various pharmaceutical products. Its structural complexity and reactivity make it a valuable component in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 6-Nitrobenzo[b]thiophene-2-carboxylic acid serves as a key intermediate for the production of various agrochemicals. Its incorporation aids in the creation of effective compounds for agricultural applications.
Used in Materials Science:
6-Nitrobenzo[b]thiophene-2-carboxylic acid may find applications in materials science due to its unique molecular structure and properties. Its potential use in this field is currently being explored.
Used in Organic Electronics:
6-Nitrobenzo[b]thiophene-2-carboxylic acid also holds promise for use in the field of organic electronics. Its distinct molecular attributes suggest possible integration into organic electronic devices and systems.

InChI:InChI=1/C9H5NO4S/c11-9(12)8-3-5-1-2-6(10(13)14)4-7(5)15-8/h1-4H,(H,11,12)

Upstream product

• 157701-72-9 4-nitro-2-fluorobenzaldehyde 
• 34084-88-3 methyl 6-nitrobenzo[b]thiophene--2--carboxylate 

Downstream Products

• 34084-88-3 methyl 6-nitrobenzo[b]thiophene--2--carboxylate 

Relevant academic research and scientific papers

Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors

STAT3 has been extensively studied as a potential antitumor target. Though studies on regulating STAT3 mainly focus on the inhibition of STAT3 phosphorylation at Tyr705 residue, the phosphorylation at Ser727 residue of STAT3 protein is also closely associated with the mitochondrial import of STAT3 protein. N, N-diethyl-7-aminocoumarin is a fluorescent mitochondria-targeting probe. In this study, a series of STAT3 inhibitors were developed by connecting N, N-diethyl-7-aminocoumarin fluorophore with benzo [b]thiophene 1, 1-dioxide moiety. All designed compounds displayed potent anti-proliferative activity against cancer cells. The representative compound 7a was mainly accumulated in mitochondria visualized by its fluorescence. STAT3 phosphorylation was inhibited by compound 7a at both Tyr705 and Ser727 residues. Compound 7a inhibited STAT3 phosphorylation whereas had no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2, indicating good selectivity of compound 7a. Moreover, compound 7a down-regulated the expression of STAT3 target genes Bcl-2 and Cyclin D1, increased ROS production and remarkably reduced the mitochondrial membrane potential to induce mitochondrial apoptotic pathway. Furthermore, compound 7a in vivo suppressed breast cancer 4T1 implanted tumor growth. Taken together, these results highlighted that compound 7a might be a promising mitochondria-targeting STAT3 inhibitor for cancer therapy.

METHOD FOR PROMOTING PLANT GROWTH

The present invention provides a method for promoting plant growth, which comprises treating a plant with at least one compound selected from a group consisting of a compound represented by the following Formula (1): and an agriculturally acceptable salt thereof, provided that a method for promoting plant growth which comprises treating plants with a compound corresponding to any one of the following (1) to (5) and an agriculturally acceptable salt thereof is excluded: (1) 4-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (2) 5-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (3) 6-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, (4) 7-(Trifluoromethyl)benzo[b]thiophene-2-carboxylic acid, and (5) Benzo[b]thiophene-2-carboxylic acid.

BENZOTHIOPHENE UREA, BENZOFURANE UREA, AND INDOLE UREA, AND USE OF THE SAME AS ALPHA-7 ACHR AGONISTS

The invention relates to novel benzothiophene urea, benzofurane urea, and indole urea, and to the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration power, learning capacity and/or memory retention.