199850-67-4 Usage
Uses
Used in Pharmaceutical Industry:
PD 166793 is used as a matrix metalloproteinase inhibitor for the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system. Its potent inhibition against specific MMPs and demonstrated therapeutic benefits in animal models make it a valuable compound for developing treatments for heart failure and diabetes.
Used in Research Applications:
PD 166793 is also used as a research tool to study the roles of various matrix metalloproteinases in different biological processes and disease states. Its selective inhibition of MMPs allows researchers to investigate the specific functions and contributions of these enzymes in cellular and molecular mechanisms, leading to a better understanding of their involvement in disease progression and potential therapeutic targets.
Biological Activity
Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 199850-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,8,5 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 199850-67:
(8*1)+(7*9)+(6*9)+(5*8)+(4*5)+(3*0)+(2*6)+(1*7)=204
204 % 10 = 4
So 199850-67-4 is a valid CAS Registry Number.
