199857-56-2

Upstream product

• 120312-94-9 C₁₈H₃₃BO 
• 199857-53-9 (2R,5S)-5-Methoxy-7-(4-methoxy-benzyloxy)-2-methyl-3-methylene-heptanal 
• 565-69-5 ethyl isopropyl ketone 
• 199857-59-5 C₃₄H₆₃BO₂Si 
• 199857-43-7 C₃₄H₆₃BO₂Si 
• 199857-44-8 (2S,5S)-5-hydroxy-7-(p-methoxybenzyloxy)-2-methyl-1-(triisopropylsiloxy)-heptan-3-one 
• 199857-46-0 (4R)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(triethylsiloxy)-hex-1-ene 
• 199857-47-1 (3S)-1-(p-methoxybenzyloxy)-5-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-hex-5-en-3-ol 
• 862379-31-5 (4S)-2-[1-(triisopropylsiloxy)-prop-2-(R)-yl]-6-(p-methoxybenzyloxy)-4-(p-nitrobenzoyloxy)-hex-1-ene 
• 862379-36-0 (2S,5S)-7-(4-Methoxy-benzyloxy)-2-methyl-5-triethylsilanyloxy-1-triisopropylsilanyloxy-heptan-3-one 
• 199857-42-6 (S)-3-methyl-4-(triisopropylsiloxy)-butan-2-one 

Relevant academic research and scientific papers

Studies in marine macrolide synthesis: Synthesis of the C1-C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions

The C1-C15 aldehyde 3, containing the AB-spiroacetal of spongistatin 1 (1), was prepared in 17 steps from methyl ketone (S)-8. The C15 and C16 stereocentres could be introduced together, relying on Felkin-Anh control, by using a boron-mediated, anti aldol coupling reaction, as in 22 → 25 and 26.