19986-16-4Relevant academic research and scientific papers
Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)-H Bonds
Miao, Jinmin,Yang, Ke,Kurek, Martin,Ge, Haibo
, p. 3738 - 3741 (2015/08/18)
The transition-metal-catalyzed direct C-H bond fluorination is an attractive synthetic tool toward the preparation of organofluorines. While many methods exist for the direct sp3 C-H functionalization, site-selective fluorination of unactivated sp3 carbons remains a challenge. Direct, highly site-selective and diastereoselective fluorination of aliphatic amides via a palladium-catalyzed bidentate ligand-directed C-H bond functionalization process on unactivated sp3 carbons is reported. With this approach, a wide variety of β-fluorinated amino acid derivatives and aliphatic amides, important motifs in medicinal and agricultural chemistry, were prepared with palladium acetate as the catalyst and Selectfluor as the fluorine source.
Research in dipropylacetic series. XII. Aliphatic ramified acids and alcohols with anticonvulsant activity
Taillandier,Benoit Guyod,Boucherle,et al.
, p. 453 - 462 (2007/10/05)
Previous results obtained about 2 propyl pentanoic acid (dipropylacetic or DPA) have been extended to other dialkylalkanoic acids having less than 14 carbon atoms and to some of their precursors (alcohols) or derivatives (amides). The effect of lengthening the chain bonding between the carbon bearing the two alkyl chains and the functional carbon on about 50 molecules is discussed. The anticonvulsant activity's length and strength often increases when lengthening that chain.
