199875-71-3 Usage
Uses
Eicosapentaenoyl Serotonin is a dual fatty acid amide hydrolase and TRPV1 antagonist.
Biological Activity
eicosapentaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin. arachidonoyl serotonin is an inhibitor of fatty acid amide hydrolase (faah) and also acts as an antagonist of transient receptor potential vanilloid-type 1 (trpv1) channels. arachidonoyl serotonin is analgesic, reducing both acute and chronic peripheral pain in rodents [1, 2]. the effects of replacement the arachidonoyl portion with eicosapentaenoic acid have not been investigated. replacement of arachidonate with saturated 11- or 12-carbon fatty acids generated compounds that potently inhibited capsaicin-induced trpv1 channel activation with an ic50 of 0.76 μm. Eicosapentaenoyl Serotonin showed no effects on blocking faah-mediated hydrolysis of arachidonoyl ethanolamide with an ic50 of > 50 μm [1].
references
[1] ortar, g. ,cascio, m.g.,de petrocellis, l., et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. journal of medicinal chemistry 50, 6554-6569 (2007).[2] maione, s. ,de petrocellis, l.,de novellis, v., et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. british journal of pharmacology 150, 766-781 (2007).
Check Digit Verification of cas no
The CAS Registry Mumber 199875-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,9,8,7 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 199875-71:
(8*1)+(7*9)+(6*9)+(5*8)+(4*7)+(3*5)+(2*7)+(1*1)=223
223 % 10 = 3
So 199875-71-3 is a valid CAS Registry Number.
