19990-27-3

Usage

Uses

Used in Chemical Synthesis:
(5Z)-5-[(4-chlorophenyl)imino]furan-2(5H)-one is used as a building block in the chemical synthesis of other organic compounds. Its unique structure and reactivity make it a valuable component in the creation of various molecules with potential applications in different industries.
Used in Pharmaceutical Research:
(5Z)-5-[(4-chlorophenyl)imino]furan-2(5H)-one is used as a starting material for the development of new pharmaceuticals. Its potential biological activity has attracted interest in the field of medicinal research, where it may contribute to the discovery of novel therapeutic agents.
Used in Agricultural Research:
In addition to its pharmaceutical applications, (5Z)-5-[(4-chlorophenyl)imino]furan-2(5H)-one is also used in agricultural research. Its potential biological activity may lead to the development of new compounds for use in the agricultural industry, such as pesticides or other agrochemicals.

Upstream product

• 7242-16-2 N-4-chlorophenyl-maleamic acid 

Downstream Products

• 72291-62-4 1-(4-chloro-phenyl)-3,3-dimethyl-5-oxa-1-aza-spiro[3.4]oct-7-ene-2,6-dione 

Relevant academic research and scientific papers

Propanephosphonic acid anhydride-mediated cyclodehydration of maleic acid monoamides

Propanephosphonic acid anhydride (T3P) has been proposed as a novel reagent for the preparation of maleic acid isoimides from the corresponding monoamides. A series of substituted aromatic and aliphatic isoimides have been prepared in good yields. The mai

Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore

Several series of compounds containing the 1,4-dioxo-2-butenyl moiety have been prepared as candidate cytotoxins, including the methyl N-arylmaleamates, methyl N-arylfumaramates, and N-arylmaleimides. In addition, the N-arylisomaleimides were synthesized which are the structural isomers of N-arylmaleimides. These compounds were evaluated against human Molt 4/C8 and CEM T-lymphocytes as well as murine L1210 cells. Methyl N-arylfumaramates showed the highest cytotoxic potencies and, in particular, methyl N-(3,4-dichlorophenyl)fumaramate is six times more potent than melphalan towards L1210 cells and is equipotent with this drug in the Molt 4/C8 assay. Electrophilicity of compounds under investigation was demonstrated by carrying out thiolation using model benzyl mercaptan on representative compounds. Methyl N-(3,4-dichlorophenyl)fumaramate and methyl N-(4-chlorophenyl)maleamate inhibited human N-myristoyltransferase, a possible molecular target, in high micromolar range. QSAR and molecular modeling revealed some correlations between different structural features of a number of the molecules and cytotoxic potencies. Methyl N-arylfumaramates were well tolerated in mice in comparison to the analogs in other series of compounds tested. The data obtained in this investigation affords guidelines for preparing new series of molecules with greater potencies.

Cyanuric chloride: Decent dehydrating agent for an exclusive and efficient synthesis of kinetically controlled isomaleimides

Starting from maleanilic and maleamic acids, a facile general approach to kinetically controlled isomaleimides has been described for the first time using cyanuric chloride as a dehydrating agent with 85-98% yields. The effect of a variety of substituents