199929-36-7Relevant academic research and scientific papers
Redox-responsive xanthene-coumarin-chlorambucil-based FRET-guided theranostics for "activatable" combination therapy with real-time monitoring
Gangopadhyay, Moumita,Mengji, Rakesh,Paul, Amrita,Venkatesh, Yarra,Vangala, Venugopal,Jana, Avijit,Singh, N. D. Pradeep
, p. 9109 - 9112 (2017)
A FRET donor-acceptor xanthene-coumarin conjugate has been designed for redox-regulated synergic treatment of photodynamic therapy and chemotherapy with real-time monitoring. The "locked" FRET pair was selectively "unlocked" by biological reducing thiols via rupture of a sacrificial disulfide linker. A distinct change in fluorescence color and selective cancer cell toxicity were observed in vitro.
