199942-74-0

Basic information

• Product Name: (S)-1-N-BOC-PIPERIDINE-2-ETHANOL
• Synonyms: 1-Piperidinecarboxylic acid, 2-(2-hydroxyethyl)-, 1,1-dimethylethyl ester, (2S)
• CAS NO: 199942-74-0
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.318
• Mol File: 199942-74-0.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 149.8 °C
• Appearance: /
• Density: 1.043
• Vapor Pressure: 1.97E-05mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.15±0.10(Predicted)
• CAS DataBase Reference: (S)-1-N-BOC-PIPERIDINE-2-ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-N-BOC-PIPERIDINE-2-ETHANOL(199942-74-0)
• EPA Substance Registry System: (S)-1-N-BOC-PIPERIDINE-2-ETHANOL(199942-74-0)

Safety Data

• Hazardous Substances Data: 199942-74-0(Hazardous Substances Data)

Usage

General Description

(S)-1-N-Boc-piperidine-2-ethanol is a chemical compound with the molecular formula C14H27NO3. It is a derivative of piperidine and has a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. (S)-1-N-Boc-piperidine-2-ethanol is known for its potential as a building block in organic synthesis, particularly in the preparation of pharmaceuticals and other biologically active compounds. It has been studied for its potential as a chiral building block in the synthesis of drug molecules. (S)-1-N-Boc-piperidine-2-ethanol is also used as a precursor in the synthesis of various molecules with potential biological activity. Additionally, it may have potential applications in medicinal chemistry and as a chiral auxiliary in asymmetric synthesis.

InChI:InChI=1/C12H23NO3/c1-12(2,3)16-11(15)13-8-5-4-6-10(13)7-9-14/h10,14H,4-9H2,1-3H3/t10-/m0/s1

Upstream product

• 1000806-51-8 (E)-(7-tert-butoxycarbonylamino)-2-heptenal 
• 199862-11-8 (S)-2-(diazoacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 159898-10-9 (S)-2-{1-[(tert-butoxy)carbonyl]piperidin-2-yl}acetic acid 
• 393827-07-1 (S)-2-vinyl-piperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1007600-14-7 N-acetyl-L-leucine (S)-2-piperidineethanol 
• 202926-14-5 tert-butyl hex-5-en-1-ylcarbamate 
• 639458-43-8 (S)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 2695-47-8 6-Bromo-1-hexene 
• 821-77-2 5-hexenylazide 
• 190967-63-6 benzyl (2S)-2-(2-hydroxyethyl)piperidine-1-carboxylate 
• 103639-57-2 (2S)-2-(2-methoxyethyl)piperidine 
• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 118811-03-3 tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate 

Downstream Products

• 199942-73-9 (S)-2-{2-[7-chloro-3-(3,5-dimethylphenyl)-6-nitro-2-oxo-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid tert-butyl ester 
• 639458-43-8 (S)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 893429-98-6 tert-butyl (S)-2-[2-(2-nitrophenylselenyl)ethyl]piperidine-1-carboxylate 
• 929917-81-7 (S)-2-[(4-benzylphenoxy)ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 1362120-17-9 C₁₉H₂₆ClNO₄ 
• 38211-56-2 precoccinelline 
• 1616089-25-8 C₃₄H₄₉NO₃Si 
• 1616089-26-9 C₃₄H₄₉NO₄Si 

Relevant articles and documents

(QUINOLINE OR ISOQUINOLINE)SULFONAMIDES OF CYCLIC AMINES AS ANTIPSYCHOTIC DRUGS

The invention relates to compounds of general formula (I) wherein: one of A1 and A2 represents a nitrogen atom and the other a carbon atom optionally substituted by halogen; the wave line between the sulfonamido moiety and B/C rings represents a single bond linking the sulfur atom to a non-bridgehead carbon atom, with the proviso that the part of ring C being detached by the dashed broken line is unsubstituted; n represents an integer from 0 to 3; Y represents a nitrogen or carbon atom; Z represents a 5-6 membered aromatic/ heteroaromatic ring optionally fused with a further aromatic or non- aromatic 5-6 membered heterocycle, the condensed ring system being linked via a non-bridgehead carbon atom. The compounds display high affinity for the D2, D3, 5-HT1A, 5-HT2A- 5-HT6 and 5-HT7 receptors and are useful for the treatment of psychotropic diseases or disorders associated with disturbances of the dopaminergic/ serotoninergic systems such as schizophrenia and autism.

Enantioselective approach to quinolizidines: Total synthesis of cermizine D and formal syntheses of senepodine G and cermizine C

The formal syntheses of C5-epi-senepodine G and C 5-epi-cermizine C have been accomplished through a novel diastereoselective, intramolecular amide Michael addition process. The total synthesis of cermizine D has been achieved throug

Asymmetric synthesis of (+)-vertine and (+)-lythrine

The total syntheses of the Lythracea alkaloids (+)-vertine and (+)-lythrine are described. Enantioenriched pelletierine is used as a chiral building block and engaged into a two step pelletierine condensation leading to two quinolizidin-2-one diastereomers in a 8:1 ratio. The major product is used in the synthesis of (+)-vertine via aryl-aryl coupling and ring closing metathesis to provide a Z-alkene α to the lactone carbonyl function. The same procedure was used for (+)-lythrine after base induced epimerization of the main quinolizidin-2-one diastereomer. Alternative classical ring closure strategies like macrolactonisation or aryl-aryl coupling failed.