199983-52-3

Upstream product

• 86731-84-2 3-methyl-5-phenyl-1H-pyrazin-2-one 
• 81225-11-8 2-chloro-3-methyl-5-phenylpyrazine 
• 86725-72-6 2-Chloro-3-methyl-5-phenylpyrazine 1-oxide 
• 1074-12-0 phenylglyoxal hydrate 
• 108-24-7 acetic anhydride 
• 199983-50-1 2-Methoxy-3-methyl-5-phenylpyrazine 1-oxide 

Relevant academic research and scientific papers

Studies on pyrazines. Part 34. Synthetic approach, stability and tautomerism of 2,6-dihydroxypyrazines

Demethylation of 2,6-dimethoxy-3,5-diphenylpyrazine with iodotrimethylsilane gives the corresponding 2,6-dihydroxy- and 2-hydroxy-6-methoxy-pyrazines, whilst the 3-methyl-5-phenyl analogue affords only monohydroxy compounds. In contrast, 2,6-dimethoxy-3,5-dimethylpyrazine decomposes completely under the demethylation conditions. Hydrolysis of 2,6-diacetoxypyrazines succeeds only in the formation of 2,6-dihydroxy-3,5-diphenylpyrazine. The stability of 2,6-dihydroxypyrazines is discussed on the basis of observations made in the synthetic approach. In addition, it has been established, on the basis of UV spectral analysis, that the 2-hydroxy-6-methoxypyrazines obtained in our work exist predominantly in the hydroxypyrazine form rather than as 1,2-dihydropyrazin-2-ones.