199990-69-7

Upstream product

• 199989-55-4 4-[4-(3-Benzyloxycarbonylamino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester 
• 199989-50-9 (E)-4-[5-Ethyl-1-methyl-4-(3-nitro-benzoyl)-1H-pyrrol-2-yl]-but-2-enoic acid ethyl ester 
• 199989-51-0 4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester 
• 199995-81-8 5-Ethyl-1-methyl-4-(3-nitro-benzoyl)-1H-pyrrole-2-carbaldehyde 
• 199995-80-7 5-Ethyl-4-(3-nitro-benzoyl)-1H-pyrrole-2-carbaldehyde 
• 121-90-4 m-nitrobenzoic acid chloride 
• 74882-32-9 1,5-bis(4-methoxyphenyl)pentan-3-one 
• 1551-06-0 2-ethyl-1H-pyrrole 

Relevant academic research and scientific papers

Pyrrole butyric acid derivatives as inhibitors of steroid 5α- reductase

A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.