200003-75-4

Upstream product

• 200003-55-0 allyl (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)1->3(2-O-benzyl-6-O-tert-butyldiphenylsilyl)-β-D-glucopyranoside 
• 200003-52-7 allyl (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)1->3(2-O-benzyl-4,6-O-benzylidene)-β-D-glucopyranoside 
• 200003-54-9 allyl (2,3,4-tri-O-benzyl-α-L-fucopyranosyl)1->3(2-O-benzyl)-β-D-glucopyranoside 
• 200003-46-9 allyl 3,4,6-tri-O-benzoyl-2-O-benzyl-β-D-glucopyranoside 
• 200003-47-0 allyl 2-O-benzyl-β-D-glucopyranoside 
• 161277-33-4 allyl 2-O-benzyl-(R)-4,6-O-benzylidene-β-D-gluco-pyranoside 
• 160412-80-6 allyl 3,4,6-tri-O-benzoyl-β-D-glucopyranoside 
• 13322-90-2 3,4,6-tri-O-benzoyl-D-glucal 
• 200003-56-1 allyl (2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)1->4[(2,3,4-tri-O-benzyl-α-L-fucopyranosyl)1->3(2-O-benzyl-6-O-tert-butyldiphenylsilyl)]-β-D-glucopyranoside 

Relevant academic research and scientific papers

Synthesis of sulfated trisaccharide ligands for the selectins

In a directed effort to elucidate the molecular factors responsible for selectin-mediated cell adhesion events as a basis for the generation of potent and specific inhibitors of these processes, we have synthesized a variety of sulfated analogs of the trisaccharide recognition epitopes Lewis a [Lea: Ga1β1→3(Fucα1→4)GlcNAc] and Lewis x [Le(x): Galβ1→4(Fucαl→3)GlcNAc]. Our divergent synthetic route allows for the synthesis of gram quantities of these sulfated trisaccharides from common intermediates in 10-20% overall yields and in no more than 15 linear steps. In addition, we have anchored the reducing end of the Lea and Le(x) trisaccharide precursors with a β- allyl aglycone, providing a single anomer of each final product and allowing for further modification into multivalent derivatives.