200060-91-9Relevant academic research and scientific papers
One-pot sequence synthesis of azetidin-2-one using diethyl chlorophosphate
Zarei, Maaroof
, p. 118 - 120 (2012)
A simple and convenient synthesis of 2-azetidinone derivatives from the reaction of a pre-mixture of amines and aldehydes with carboxylic acids in the presence of diethyl chlorophosphate by [2+2] cycloaddition reaction is described. Separation and purification of imines as intermediates were not required. The methodology is convenient and good to excellent yields of products were obtained with simple purification.
