200064-39-7

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-Bromopyridin-4-yl)Morpholine is used as a chemical intermediate for the synthesis of various pharmaceuticals, leveraging its antifungal, antiviral, and anticancer properties to contribute to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical field, 4-(3-Bromopyridin-4-yl)Morpholine is utilized as a building block in the production of different agrochemicals, helping to create substances that can protect crops from fungal and viral infections, thereby enhancing agricultural productivity.
Used in Organic Compounds Production:
4-(3-Bromopyridin-4-yl)Morpholine also serves as a key component in the synthesis of a wide range of organic compounds, further expanding its applications across various chemical and industrial processes.

Upstream product

• 1413439-93-6 C₉H₁₂N₂O₂ 
• 109-00-2 3-HYDROXYPYRIDINE 
• 110-91-8 morpholine 
• 1413439-82-3 C₉H₁₁BrF₃NO₃SSi 
• 1413439-81-2 C₁₂H₁₉BrN₂O₂Si 
• 625-92-3 3,5-dibromopyridine 

Relevant academic research and scientific papers

Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model

The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di- and trisubstituted pyridines in an efficient and highly controlled manner using transient 3,4-pyridyne intermediates. Previous efforts to employ 3,4-pyridynes for the construction of substituted pyridines were hampered by a lack of regiocontrol or the inability to later manipulate an adjacent directing group. The strategy relies on the use of proximal halide or sulfamate substituents to perturb pyridyne distortion, which in turn governs regioselectivities in nucleophilic addition and cycloaddition reactions. After trapping of the pyridynes generated in situ, the neighbouring directing groups may be removed or exploited using versatile metal-catalysed cross-coupling reactions. This methodology now renders 3,4-pyridynes as useful synthetic building blocks for the creation of highly decorated derivatives of the medicinally privileged pyridine heterocycle.

Complex base-induced generation of 3,4-didehydropyridine derivatives: New access to aminopyridines or pyridones

The complex base, NaNH2-tert-BuONa, in THF easily transforms 3-bromopyridine and 2-pyridone derivatives into the corresponding hetarynes. The reaction of representative amines (dialkylamines, morpholine, piperidine) with these reactive intermediates leads to the preparation of aminopyridines in good yields and illustrates the synthetic usefulness of such reactions.