200066-13-3

Upstream product

• 187479-00-1 (2R,3S,5R)-5-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 221894-42-4 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-<<(dimethylamino)methylidene>amino>-3-iodo-1H-pyrazolo<3,4-d>pyrimidine 

Downstream Products

• 221894-51-5 1-<2-Deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(dimethylamino)methylidene>amino>-3-(hex-1-ynyl)-1H-pyrazolo<3,4-d>pyrimidine 
• 221894-52-6 1-<2-Deoxy-5-O-(4,4'-dimethoxytriphenylmethyl)-β-D-erythro-pentofuranosyl>-4-<<(dimethylamino)methylidene>amino>-3-(2-phenylethynyl)-1H-pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

Duplex stability of oligonucleotides containing 7-substituted 7-deaza- and 8-aza-7-deazapurine nucleosides

The synthesis of 7-substituted 7-deaza- and 8-aza-7-deazapurine 2'deoxyribonucleosides, their incorporation into oligonucleotides, and the stability of corresponding duplexes is described.

Synthesis of oligonucleotides containing pyrazolo[3,4-d]-pyrimidines: The influence of 7-substituted 8-aza-7-deazaadenines on the duplex structure, and stability

The phosphoramidites 2a-d derived from 7-bromo- (Ib), 7-iodo- (le), 7-(hex-l-ynyl)- (Id), and 7-(2-phenylethynyl)(le) 8-aza-7-deaza-2'-deoxyadenosine were prepared. They were employed in the solid:phase synthesis of various oligonucleotides containing the