20007-01-6Relevant academic research and scientific papers
Catalytic Manufacturing Method for Imine Having No Substituent Group on the Nitrogen, and Use for the Imine Produced
-
Paragraph 0104; 0105, (2015/12/23)
The present invention relates to a method for manufacturing an imine having no substituent group on the nitrogen by using, as a catalyst, a metal complex on an organic azide compound, and more specifically relates to a method in which a metal-complex catalyst is used to produce, from an organic azide having an alpha-hydrogen, an imine having no substituent group on the nitrogen via a continuous nitrogen removal and 1,2-hydrogen transfer reaction. The imine having no substituent group on the nitrogen manufactured by means of the method of the present invention can synthesise diverse coupling products comprising amine compounds by means of reactions with diverse nucleophiles.
Reductive amination using a combination of CaH2 and noble metal
Guyon, Carole,Da Silva, Eric,Lafon, Romain,Mtay, Estelle,Lemaire, Marc
, p. 2292 - 2298 (2015/02/05)
Amines were prepared by a reductive amination reaction in the presence of calcium hydride and Pt/C. The in situ formation of water seems to be the key to activate CaH2 to reduce the intermediate imine.
