20010-99-5

Basic information

• Product Name: (PYRAZIN-2-YLMETHYL)AMINE
• Synonyms: RARECHEM AL BW 0125;(PYRAZIN-2-YLMETHYL)AMINE;2-AMINOMETHYL PYRAZINE;2-(Aminomethyl)pyradine;1-Pyrazin-2-ylmethanamine hydrochloride;2-Aminomethylpyrazine ,97%;2-Pyrazin-2-ylmethanamine;2-Pyrazinemethanamine
• CAS NO: 20010-99-5
• Molecular Formula: C₅H₇N₃
• Molecular Weight: 109.13
• EINECS: 1312995-182-4
• Product Categories: Nitrogen cyclic compounds;Piperazine series
• Mol File: 20010-99-5.mol

Chemical Properties

• Melting Point: 125 °C
• Boiling Point: 207.53 °C at 760 mmHg
• Flash Point: 101.324 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.224mmHg at 25°C
• Refractive Index: 1.557
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.13±0.40(Predicted)
• CAS DataBase Reference: (PYRAZIN-2-YLMETHYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (PYRAZIN-2-YLMETHYL)AMINE(20010-99-5)
• EPA Substance Registry System: (PYRAZIN-2-YLMETHYL)AMINE(20010-99-5)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• HazardClass: IRRITANT
• Hazardous Substances Data: 20010-99-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(Pyrazin-2-ylmethyl)amine is used as a building block for the synthesis of various pharmaceutical compounds. Its presence in the structure of these compounds can contribute to their therapeutic properties and effectiveness in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, (Pyrazin-2-ylmethyl)amine is used as a key component in the development of agrochemical products. Its incorporation into these products can enhance their performance and efficiency in agricultural applications, such as pest control and crop protection.
Used in Dye Industry:
(Pyrazin-2-ylmethyl)amine is used as a precursor in the production of dyes. Its chemical properties allow for the creation of dyes with specific color characteristics and improved stability, making them suitable for various applications in the textile, printing, and other industries.
Used in Polymer Industry:
In the polymer industry, (Pyrazin-2-ylmethyl)amine is used as a monomer or a component in the synthesis of polymers. Its incorporation into polymer structures can result in materials with unique properties, such as improved strength, flexibility, or resistance to environmental factors.
Used in Flavor and Fragrance Industry:
(Pyrazin-2-ylmethyl)amine is used as a flavoring agent or a fragrance component in the food and beverage industry. Its natural occurrence in many foods and beverages allows it to contribute to the overall taste and aroma profile of these products, enhancing their sensory appeal.

InChI:InChI=1/C5H7N3/c6-3-5-4-7-1-2-8-5/h1-2,4H,3,6H2

Upstream product

• 19847-12-2 2-pyrazine carbonitrile 
• 20584-30-9 2-(pyrazin-2-ylmethyl)isoindoline-1,3-dione 
• 39204-47-2 2-(chloromethyl)pyrazine 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 6705-33-5 pyrazin-2-ylmethanol 

Downstream Products

• 90176-04-8 N-pyrazin-2-ylmethyl-2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonamide 
• 90176-14-0 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo<1,5-a>pyrazine 
• 1158945-82-4 (Z)-2-{1-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}-N-(pyrazin-2-ylmethyl)acetamide 
• 1238062-35-5 2-[5-phenyl-1H-pyrazol-3-yl]-1H-indole-6-carboxylic acid (pyrazin-2-ylmethyl)-amide 
• 1238062-57-1 2-(5-benzyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acid (pyrazin-2-ylmethyl)-amide 
• 1238062-25-3 2-(4-phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acid (pyrazin-2-ylmethyl)amide 
• 1174122-63-4 (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid 
• 1242332-62-2 (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylate sodium salt 
• 1242332-70-2 (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid ethanolamine salt 
• 1242332-77-9 (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a]pyrazine-1-carboxylic acid (2S)-malic acid salt 
• 1242332-81-5 (R)-7-[3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid (2S,3S)-2,3-dihydroxybutanedioic acid 
• 959238-29-0 3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo [1,5-a] pyrazine 
• 1152439-77-4 (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester 
• 1152440-32-8 (R)-[3-oxo-1-(2,4,5-trifluorobenzyl)-3-(1-bromo-3-trifluoromethyl-5,6-dihydro-8H-imidazo[1,5-a]pyrazin-7-yl)-propyl]-carbamic acid t-butyl ester 

Relevant articles and documents

Targeted structural modification of spin crossover complexes: pyridine vs pyrazine

2-(Aminomethyl)pyrazine has been prepared in five steps from 2-pyrazine carboxylic acid. From this key amine, two new bis-terdentate triazole-based ligands which feature pendant pyrazine groups, PZMAT and PZMPT (4-amino- and 4-pyrrolyl-3,5-bis{[(2-pyrazylmethyl)amino]methyl}-4H-1,2,4-triazole, respectively), and two dinuclear complexes of them, [FeII 2(PZMAT)2](BF4)4?MeOH?2H2O (1?MeOH?2H2O) and [FeII 2(PZMPT)2](BF4)4?3H2O (2?3H2O), have been prepared. A structure determination at 100?K on 2?3.5MeCN confirmed that the ligands adopt the expected binding mode, providing all twelve donors to the two iron(II) centres and two N1,N2-triazole bridges between them. Both undergo gradual incomplete spin transitions: at room temperature 1?MeOH?2H2O and 2?3H2O are approximately two-thirds to three-quarters [HS-HS], dropping to mostly ‘[HS-LS]’ at 50?K. The structure determination and M?ssbauer spectroscopy of 2 qualitatively support this. These findings are consistent with the pendant pyrazines providing a somewhat higher field strength than the pendant pyridines do in the analogous PMRT complexes.

Compound with nitrogen-containing bridge ring, spiro or fused ring structure and application thereof

The invention discloses a compound with a nitrogen-containing bridge ring, spiro or fused ring structure and application of the compound. The compound has an obvious inhibition effect on the activityof protein kinase, can be used as a BTK inhibitor for preparing drugs for treating BTK-mediated diseases including, but not limited to, autoimmune diseases, malignant tumors and the like, and has a wide application prospect.

MANUFACTURING METHOD OF OPTICAL ACTIVE SECONDARY ALCOHOL

PROBLEM TO BE SOLVED: To provide a method for manufacturing optical active secondary alcohol with high optical purity by hydrogenating a substrate carbonyl compound using a ruthenium complex with a specific optical active diphosphine compound and an amine compound of which synthesis is easy as ligands as a catalyst. SOLUTION: The manufacturing method of optical active secondary alcohol including reacting a substrate carbonyl compound (excluding 3-quinuclidinone, a 3-quinuclidinone derivative having a substituent, and ketone having an aromatic hydrocarbon group and a heterocycle) with hydrogen and/or a hydrogen-donating compound in a presence of a ruthenium complex selected from a compound represented by the following general formula (1) RuXYAB (1) [X and Y are same or different, represent a hydrogen atom or an anionic group, A represents optical active diphosphine represented by the general formula (2), and B represents an amine compound represented by the following general formula (3)]. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPO&INPIT

BRUTON'S TYROSINE KINASE INHIBITORS

Bruton's tyrosine kinase (Btk) inhibitors have the following Formula (I).

TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES SALTS, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The present invention relates to (R)-7-[3-Amino-4-(2,4,5-trifluoro-phenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid pharmaceutical salts, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as a dipeptidyl peptidase IV inhibitor.

PROCESS FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL

[Object] The object of this invention is to provide a method for producing an optically active secondary alcohol at a high optical purity by hydrogenating a substrate carbonyl compound at a high efficiency using as a catalyst a ruthenium complex bearing as a ligand certain optically active diphosphine compound and a readily synthesized amine compound. [Solution] The method of producing an optically active secondary alcohol according to the present invention is characterized in that a substrate carbonyl compound (provided that 3-quinuclidinone, 3-quinuclidinone derivative having a substituent, and a ketone having an aromatic hydrocarbon group and a heterocycle are excluded) is reacted with hydrogen and/or a hydrogen donating compound in the presence of a ruthenium complex selected from the compounds expressed by following general formula (1) RuXYAB (1) [in the general formula (1), X and Y are the same or different from each other and denote a hydrogen atom or an anionic group, A denotes an optically active diphosphine expressed by the general formula (2), B denotes an amine compound expressed by following general formula (3)].

BIARYL ETHER SULFONAMIDES AND THEIR USE AS THERAPEUTIC AGENTS

This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

SALTS OF TETRAHYDROIMIDAZO Y1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USE THEREOF

Pharmaceutical salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-formic acid, their preparation methods, compositions containing the said pharmaceutical salts and their use as medicaments, especially as dipeptidyl peptidase IV (DPP-IV) inhibitors are disclosed.

TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE DERIVATIVES SALTS, PREPARATION METHODS AND MEDICINAL USE THEREOF

Pharmaceutically acceptable salts of (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)-butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-formic acid, their preparation methods, compositions containing the said pharmaceutical salts and their use as medicaments, especially as dipeptidyl peptidase IV (DPP-IV) inhibitors are disclosed.

TETRAHYDRO-IMIDAZOY1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF

Tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula ( I ), their preparation methods, pharmaceutical compositions containing the derivatives and uses thereof as medicaments, especially as dipeptidyl peptidase IV inhibitor, wherein the substituents of formula ( I ) are defined as same as the description.