200118-20-3Relevant articles and documents
Asymmetric Synthesis of Alkyl Fluorides: Hydrogenation of Fluorinated Olefins
Ponra, Sudipta,Yang, Jianping,Kerdphon, Sutthichat,Andersson, Pher G.
, p. 9282 - 9287 (2019/05/28)
The development of new general methods for the synthesis of chiral fluorine-containing molecules is important for several scientific disciplines. We herein disclose a straightforward method for the preparation of chiral organofluorine molecules that is ba
Direct electrophilic α-fluorination of imines: Efficient synthesis of mono-and difluoroimines
Verniest, Guido,Van Hende, Eva,Surmont, Riccardo,De Kimpe, Norbert
, p. 4767 - 4770 (2007/10/03)
(Chemical Equation Presented) A mild and efficient procedure to synthesize α-fluoro- and α,α-difluoroimines was developed. Various N-alkylimines derived from acetophenones were successfully monofluorinated using NFSI (N-fluorobenzenesulfonimide) in a mixture of CH3CN and DMF at 0°C. Alternatively, the same procedure without DMF gave rise to difluorinated imines when performed at room temperature. The obtained α- and α,α-difluorinated imines were subsequently reduced to give the corresponding β-fluoro- and β,β-difluoroamines in good yield.
Diastereoselective electrophilic fluorination of enantiopure α-silylketones using N-fluoro-benzosulfonimide: Regio- and enantioselective synthesis of α-fluoroketones
Enders,Faure,Potthoff,Runsink
, p. 2307 - 2319 (2007/10/03)
α-Fluoroketones 6 are synthesized in good yields and high enantiomeric excesses (ee = 87-≥96%) from the corresponding simple cyclic and acyclic ketone precursors. The procedure involves a regio- and diastereoselective electrophilic fluorination of enantio
