200119-12-6

Upstream product

• 65-71-4 thymin 
• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 200118-88-3 (2R,3S,5S)-3-Allyl-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-ol 
• 200119-10-4 2-{3-[(2R,3S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-trimethylsilanyloxy-tetrahydro-furan-3-yl]-propyl}-isoindole-1,3-dione 
• 200119-09-1 1-[(4S,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-hydroxy-propyl)-4-trimethylsilanyloxy-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 200118-87-2 (2R,5S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methoxy-dihydro-furan-3-one 
• 123122-47-4 (2R,3S,5S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-ol 
• 136918-14-4 phthalimide 

Relevant academic research and scientific papers

Synthesis and hybridization properties of β- and α-oligodeoxynucleotides containing β- and α-1-(3-C-allyl-2-deoxy-D-erythro-pentofuranosyl)thymine and α-1-[3-C-(3-aminopropyl)-2-deoxy-D-erythro-pentofuranosyl]thymine

Convergent synthesis of β- and α-1-(3-C-allyl-2-deoxy-D-erythro-pentofuranosyl)thymine and their incorporation into β- and α-oligodeoxynucleotides (ODNs) is described. The thermal stabilities of duplexes formed between modified ODNs and complementary single-stranded DNA and RNA have been evaluated. In all cases stable duplexes are formed, but whereas β-ODNs containing β-3′-C-allylthymidine show moderately lowered thermal stability towards both DNA and RNA, α-ODNs containing α-3′-C-allylthymidine show significantly increased thermal stabilities compared with the corresponding β-ODN reference duplexes. Even more stable duplexes towards both DNA and RNA have been obtained using an α-ODN containing one α-1-[3-C-(3-aminopropyi)-2-deoxy-D-erythro-pentofuranosyl]thymine monomer.