20016-63-1Relevant academic research and scientific papers
Structure-activity relationship study of asiatic acid derivatives against beta amyloid (Aβ)-induced neurotoxicity
Jew, Sang-Sup,Yoo, Chi-Hyoung,Lim, Doo-Yeon,Kim, Heeman,Mook-Jung, Inhee,Whan Jung, Min,Choi, Heesung,Jung, Young-Hoon,Kim, Heedoo,Park, Hyeung-Geun
, p. 119 - 121 (2000)
8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against Aβ-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.
Synthesis and biological evaluation of novel asiatic acid derivatives with anticancer activity
Gon?alves, Bruno M. F.,Salvador, Jorge A. R.,Marín, Silvia,Cascante, Marta
, p. 3967 - 3985 (2016)
Asiatic acid (AA) is a pentacyclic triterpenoid with recognized anticancer properties. Structural modification of AA may afford derivatives with improved anticancer potency. Hence, in this paper, a series of new lactol and A-nor AA derivatives were prepared, and their antiproliferative activities against several human cancer cell lines and a non-tumoral fibroblast cell line (BJ) were tested. Among all the derivatives tested, compound 24 proved to be the most active compound, with IC50 values ranging from 0.11 μM to 0.65 μM for cancer cell lines. The molecular mechanisms underlying its antiproliferative activity were further investigated using the HeLa cell line. Our results showed that treatment of HeLa cells with compound 24 led to cell-cycle arrest at the G0/G1 phase, which was associated with an upregulation of p21cip1/waf1 and p27kip1 and a downregulation of cyclin D3. Moreover, compound 24 induced apoptotic HeLa cell death via the activation of caspase-9, caspase-8, and caspase-3. The downregulation of the Bcl-2 and Bid proteins and the upregulation of the Bax protein suggest that the mitochondrial pathway is activated during the apoptotic process.
TRITERPENE ACIDS FROM SOME PAPUA NEW GUINEA TERMINALIA SPECIES
Collins, David J.,Pilotti, Carmel A.,Wallis, Adrian F. A.
, p. 881 - 884 (2007/10/02)
The trihydroxylated triterpene acids arjunolic acid and asiatic acid were found in ether extracts of the woods of Terminalia brassi and of T. complanata.Asiatic acid has not previously been reported as a constituent of the genus Terminalia.A similar extract of T. impediens yielded the tetrahydroxy acid terminolic acid as the major constituent; this acid was also detected as a minor constituent of T. complanata.Terminolic acid, however, does not occur in glycosidic combination in Centella asiatica, as has been recently reported. Key Word Index - Terminalia brassii; T. impediens; T. complanata; Combretaceae; wood; triterpenoids; arjunolic acid; asiatic acid; terminolic acid; chemotaxonomy.
