200184-53-8

Basic information

• Product Name: S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE
• Synonyms: S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE;S-1-Boc-piperidine-2-carboxylic acid Methylester;Boc-S-piperidine-2-carboxylic acid Methyl ester;(S)-1-tert-Butyl 2-Methyl piperidine-1,2-dicarboxylate;Methyl (S)-1-Boc-2-piperidinecarboxylate
• CAS NO: 200184-53-8
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.29944
• Mol File: 200184-53-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 307.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -3.28±0.40(Predicted)
• CAS DataBase Reference: S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(200184-53-8)
• EPA Substance Registry System: S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(200184-53-8)

Safety Data

• Hazardous Substances Data: 200184-53-8(Hazardous Substances Data)

Usage

General Description

S-Methyl 1-Boc-piperidine-2-carboxylate is a chemical compound used in the synthesis of pharmaceuticals and other organic molecules. It is a piperidine derivative with a methyl group and a Boc (tert-butyloxycarbonyl) group attached to the nitrogen and carboxylic acid functional groups, respectively. The Boc group serves as a protecting group, preventing unwanted reactions at the nitrogen atom during chemical synthesis, while the methyl group modifies the electronic and steric properties of the piperidine ring. S-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE is valuable in the field of medicinal chemistry and organic synthesis for its ability to introduce specific functionality into targeted molecules in a controlled manner.

Upstream product

• 155905-80-9 1-tert-butyl 2-methyl 1,4,5,6-tetrahydropyridine-1,2-dicarboxylate 
• 79-22-1 methyl chloroformate 
• 123387-55-3 1-t-butoxycarbonyl-2-tributylstannylpiperidine 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 768-33-2 phenyldimethylsilyl chloride 

Downstream Products

• 150521-32-7 (S)-1-N-Boc-piperidine-2-al 
• 68682-28-0 (2,8-bis-trifluoromethyl-quinolin-4-yl)-piperidin-2-yl-methanol; hydrochloride 

Relevant articles and documents

Asymmetric lithiation trapping of N -boc heterocycles at temperatures above -78°C

The asymmetric lithiation trapping of N-Boc heterocycles using s-BuLi/chiral diamines at temperatures up to -20°C is reported. Depending on the N-Boc heterocycle, lithiation is accomplished using s-BuLi and (-)-sparteine or the (+)-sparteine surrogate in the temperature range -50 to -20°C for short reaction times (2-20 min). Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered functionalized N-Boc heterocycles in 47-95% yield and 77:23-93:7 er. With N-Boc pyrrolidine, trapped products can be generated in ～90:10 er even at -20°C.

Aromatic amidine derivatives useful as selective thrombin inhibitors

The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.

Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids wit