200185-84-8Relevant academic research and scientific papers
A facile synthesis of benzofuran derivatives: A useful synthon for preparation of trypsin inhibitor
Sekizaki, Haruo,Itoh, Kunihiko,Toyota, Eiko,Tanizawa, Kazutaka
, p. 237 - 243 (2007/10/03)
Mono-substituted 2-methylbenzo[b]furans were prepared by Claisen rearrangement of corresponding allyl phenyl ethers and subsequent bis(benzonitrile)palladium(II) chloride-mediated cyclization of o-allylphenols.
Aromatic amidine derivatives useful as selective thrombin inhibitors
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, (2008/06/13)
The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.
