200188-57-4Relevant academic research and scientific papers
A convenient and efficient one-pot synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids by curtius rearrangement
He, Xin,Cao, Chong,Liang, Jingwei,Li, Xinyang,Zhang, Tingjian,Meng, Fanhao
, p. 386 - 390 (2017)
A convenient and efficient method was developed for the synthesis of arylacetones from (E)-3-aryl-2-methylacrylic acids through a Curtius rearrangement. The Curtius rearrangement of (E)-3-aryl-2-methylacryloyl azides and subsequent hydrolysis proceeded at mild temperatures in a two-phase medium of carbon tetrachloride and water containing a catalytic amount of tetrabutylammonium bromide to give the corresponding derivatives in 82-93% yield.
Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents
Wu, Yuelin,Min, Xiao,Zhuang, Chunlin,Li, Jin,Yu, Zhiliang,Dong, Guoqiang,Yao, Jiangzhong,Wang, Shengzheng,Liu, Yang,Wu, Shanchao,Zhu, Shiping,Sheng, Chunquan,Wei, Yunyang,Zhang, Huojun,Zhang, Wannian,Miao, Zhenyuan
, p. 545 - 551 (2014/07/07)
In an effort to expand the structure-activity relationship of the natural anticancer compound piperlongumine, we have prepared sixteen novel piperlongumine derivatives with halogen or morpholine substituents at C2 and alkyl substituents at C7. Most of 2-halogenated piperlongumines showed potent in vitro activity against four cancer cells and modest selectivity for lung normal cells. The highly active anticancer compound 11h exhibited obvious ROS elevation and excellent in vivo antitumor potency with suppressed tumor growth by 48.58% at the dose of 2 mg/kg. The results indicated that halogen substituents as electrophilic group at C2 played an important role in increasing cytotoxicity.
