200191-78-2

Upstream product

• 171865-51-3 3,4-di-O-benzyl-1,5-dideoxy-1,5-epithio-D-glucitol 
• 157363-84-3 1,2:5,6-dianhydro-3,4-di-O-benzyl-L-iditol 

Relevant academic research and scientific papers

Synthesis of thiosugars as weak inhibitors of glycosidases

A series of enantiomerically pure thiosugars (1,6-dideoxy-1,6-thio-D- mannitol or L-iditol, 1,5-dideoxy-1,5-thio-L-gulitol or D-glucitol and 2,5- dideoxy-2,5-thio-L-iditol or D-mannitol, and their corresponding sulfoxide or sulfone) was synthesized via thiocyclization of C2-symmetric bis-epoxides, and subsequently followed by ring isomerization in few cases. These compounds have been evaluated as inhibitors of several glycosidases (α- and β-D- glucosidases, α-D-mannosidase and α-L-fucosidase).