2002-68-8

Usage

Uses

Used in Pesticide Industry:
(2,6-DINITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is used as an intermediate in the synthesis of 2,6-dinitroaniline derivatives for their potential pesticide properties. These derivatives are being explored for their ability to control and manage pests in agricultural settings, thereby contributing to increased crop yields and protection against damage caused by insects and other pests.
As an intermediate in chemical synthesis:
(2,6-DINITRO-4-TRIFLUOROMETHYL-PHENYL)-HYDRAZINE is utilized in the synthesis of various chemical products, including pharmaceuticals, dyes, and other specialty chemicals. Its unique structure allows it to serve as a building block for the development of new compounds with diverse applications across different industries.

InChI:InChI=1/C7H5F3N4O4/c8-7(9,10)3-1-4(13(15)16)6(12-11)5(2-3)14(17)18/h1-2,12H,11H2

Upstream product

• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 
• 317-70-4 2-methoxy-1,3-dinitro-5-(trifluoromethyl)benzene 

Downstream Products

• 74990-44-6 5-Amino-4-cyan-1-(2,6-dinitro-4-trifluormethylphenyl)pyrazol 

Relevant academic research and scientific papers

Synthesis and free radical scavenging activity of new hydroxybenzylidene hydrazines

Hydroxybenzylidene hydrazines exhibit a wide spectrum of biological activities. Here, we report synthesis and free radical scavenging activity of nine new N-(hydroxybenzylidene)-N0-[2,6-dinitro-4-(trifluoromethyl)]phenylhydrazines. The chemical structures

Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

Mutation of the proto-oncogene K-Ras is one of the most common molecular mechanisms in non-small cell lung cancer. Many drugs for treating lung cancer have been developed, however, due to clinical observed K-Ras mutations, corresponding chemotherapy and targeted therapy for such mutation are not efficient enough. In this study, on the basis of the crystal structure of K-Ras, 21 analogues (TKR01–TKR21) containing urea or thiourea were rationally designed, which can effectively inhibit the lung cancer cell A549 growth. The designing of these compounds was based on the structure of K-Ras protein, and the related groups were replaced by bioisosteres to improve the affinity and selectivity. Biological testing revealed that compound TKR15 could significantly inhibit the proliferation of A549 cell with IC50 of 0.21 μM. Docking analysis showed that the TKR15 can effectively bind to the hydrophobic cavity and form a hydrogen bond with the Glu37. In addition, through flow apoptosis assay and immunofluorescence staining assay, it confirmed that this compound can inhibit A549 cell proliferation with the mechanism of blocking K-RasG12V protein and effector proteins interactions through the apoptotic pathway. In conclusion, our studies in finding novel potent compound (TKR15) with confirmed mechanism showed great potential for further optimisation and other medicinal chemistry relevant studies.

SOLID PHASE SUPPORT FOR NUCLEIC ACID SYNTHESIS AND METHOD FOR PRODUCING NUCLEIC ACID USING THE SAME

PROBLEM TO BE SOLVED: To provide a solid phase support that can be used in nucleic acid synthesis with high yield, high efficiency and high selectivity, and a method for producing a nucleic acid using the same. SOLUTION: A solid phase support for nucleic

Compound comprising urea and thiourea structures and synthesis method and application of compound

The invention relates to an organic small molecular compound comprising urea and thiourea structures in a formula I and a synthesis method and application of the compound. According to in-vitro antitumor activity tests, the compound has high antitumor act

Phosphotriesters Approach to the Synthesis of Oligonucleotides: A Reappraisal

The phosphotriester approach to the synthesis of oligodeoxyribo- and oligoribo-nucleotides in solution has been reinvestigated.The efficacy of mesitylene-2-sulfonyl chloride (MSCl) 15a, 2,4,6-triisopropylbenzenesulfonyl chloride (TrisCl) 15b, 4-bromobenzenesulfonyl chloride 15c, naphthalene-1-sulfonyl chloride 39, and 2- and 4-nitrobenzenesulfonyl chlorides 40a and 40b, respectively, as activating agents has been examined.The latter arenesulfonyl chlorides have been used in conjunction with the following nucleophilic catalysts: 1-methylimidazole, 3-nitro-1H-1,2,4-triazole 19, 5-(3-nitrophenyl)-1H-tetrazole 20a, 5-(3,5-dinitrophenyl)-1H-tetrazole 20b, 5-(1-methylimidazol-2-yl)-1H-tetrazole 21, 5--1H-tetrazole 22, 4-ethoxypyridine 1-oxide 14a, 4,6-dinitro-1-hydroxybenzotriazole 29a, 1-hydroxy-4-nitro-6-(trifluoromethyl)benzotriazole 29b, 1-hydroxy-5-phenyltetrazole 30a and 1-hydroxy-5-(3-nitrophenyl)tetrazole 30b.The rates of formation and yields of the fully protected dideoxyribonucleoside and diribonucleoside phosphates 37 and 47, respectively, were determined using various combinations of activating agents and nucleophilic catalysts.Although 2- and 4-nitrobenzenesulfonyl chlorides 40a and 40b, respectively, proved to be the most powerful activating agents, their use in the deoxy-series led to the formation of by-products and hence to unsatisfactory isolated yields of the dideoxyribonucleoside phosphate 37.

Benzocrown Ether Hydrazones as Extractants for Alkali Metal Ions

Four types of benzo-15-crown-5 and benzo-18-crown-6 derivatives bearing a substituted hydrazone moiety as a proton-dissociable chromogenic group were synthesized and the solvent extraction behaviors of these compounds for alkali metal ions were evaluated spectrophotometrically.Benzo-15-crown-5 and -18-crown-6 hydrazones with 2,4-dinitro-6-(trifluoromethyl)phenyl or 2,6-dinitro-4-(trifluoromethyl)phenyl groups extracted alkali metal ions predominantly as 2:1 and 1:1 (crown ether:metal ion) complexes, respectively, from an aqueous alkaline solution into 1,2-dichloroethane and these ligands exhibited high K+-selectivity.The composition of the extracted species and the K+-selectivity depended on the polarity of the extraction solvent used.In particular, 2:2 complexes of several alkali metal ions with benzo-15-crown-5 and -18-crown-6 hydrazones bearing a 2,4-dinitro-6-(trifluoromethyl)phenyl group were readily extracted from an aqueous solution into chloroform.