200214-60-4

Basic information

• Product Name: BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER
• Synonyms: BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER;ethyl 2-(3,5-dichlorophenyl)acetate
• CAS NO: 200214-60-4
• Molecular Formula: C10H10Cl2O2
• Molecular Weight: 233.0912
• Mol File: 200214-60-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER(200214-60-4)
• EPA Substance Registry System: BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER(200214-60-4)

Safety Data

• Hazardous Substances Data: 200214-60-4(Hazardous Substances Data)

Usage

General Description

Benzeneacetic acid, 3,5-dichloro-, ethyl ester is a chemical compound with the molecular formula C10H9Cl2O2. It is an ethyl ester of 3,5-dichlorobenzoic acid, which is commonly used as an intermediate for the synthesis of various pharmaceuticals and agrochemicals. BENZENEACETIC ACID, 3,5-DICHLORO-, ETHYL ESTER is a colorless to pale yellow liquid with a strong, sweet, and fruity odor. It is primarily used as an intermediate in the production of various chemical products, and it is important to handle it with caution due to its potential health hazards, including skin and eye irritation and respiratory issues when inhaled.

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 67492-50-6 (3,5-dichlorophenyl)boronic acid 
• 51719-65-4 2-(3,5-dichlorophenyl)acetic acid 

Relevant articles and documents

Synthesis of α-aryl esters and nitriles: Deaminative coupling of α-aminoesters and α-aminoacetonitriles with arylboronic acids

Transition-metal-free synthesis of α-aryl esters and nitriles using arylboronic acids with α-aminoesters and α-aminoacetonitriles, respectively, as the starting materials has been developed. The reaction represents a rare case of converting C(sp3)-N bonds into C(sp3)-C(sp2) bonds. The reaction conditions are mild, demonstrate good functional-group tolerance, and can be scaled up. Touch base: A transition-metal-free protocol for the synthesis of α-aryl esters and nitriles by deaminative coupling is presented. Strong bases and transition-metal catalysts are not needed. The new synthetic method uses readily available starting materials and demonstrates wide substrate scope.

AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.