20028-40-4

Basic information

• Product Name: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE
• Synonyms: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE;2-(AMINOMETHYL)-1-METHYL-1H-BENZIMIDAZOLE;2-(AMINOMETHYL)-1-METHYLBENZIMIDAZOLE;1-(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHANAMINE;C-(1-METHYL-1H-BENZOIMIDAZOL-2-YL)-METHYLAMINE;2-(Aminomethyl)-1-methyl-1H-benzimidazole 97%;1H-Benzimidazole-2-methanamine,1-methyl-(9CI);[(1-methyl-1H-benzimidazol-2-yl)methyl]amine hydrochloride
• CAS NO: 20028-40-4
• Molecular Formula: C₉H₁₁N₃
• Molecular Weight: 161.2
• Product Categories: BENZIMIDAZOLE
• Mol File: 20028-40-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 261 °C
• Boiling Point: 333℃
• Flash Point: 155℃
• Appearance: /
• Density: 1.22
• Vapor Pressure: 0.000143mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.51±0.29(Predicted)
• CAS DataBase Reference: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE(20028-40-4)
• EPA Substance Registry System: (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE(20028-40-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3259
• Hazardous Substances Data: 20028-40-4(Hazardous Substances Data)

Usage

Uses

1-Methyl-2-benzimidazolemethanamine inhibits binding of p34 protein to NEDD4-1 protein and can be used as an anti-cancer agent. It can also be used as an HIV integrase inhibitor.

InChI:InChI=1/C9H11N3/c1-12-8-5-3-2-4-7(8)11-9(12)6-10/h2-5H,6,10H2,1H3/p+1

Upstream product

• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 1442637-90-2 C₁₅H₂₁N₆⁽¹⁺⁾*Cl^(1-) 
• 4760-35-4 2-chloromethyl-1-methyl-1H-benzimidazole 
• 459-73-4 GlyOEt*HCl 
• 53332-79-9 2-aminomethyl-1-methylbenzimidazole dihydrochloride 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 949304-63-6 (2-hydroxyphenyl)[5-(1-methyl-1H-benzimidazol-2-yl)-1H-pyrrol-3-yl]methanone 
• 1422360-66-4 C₂₀H₂₀N₆O₂ 
• 1442637-86-6 bis(2,4-dimethylphenylthiomethyl)-(1-methylbenzimidazol-2-ylmethyl)amine 
• 1612183-60-4 6-(2,3-dimethylphenyl)-4-N-[(1-methyl-1H-1,3-benzodiazol-2-yl)methyl]pyrimidine-2,4-diamine 
• 440098-94-2 2-[1-(3,4-Dimethoxy-benzyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepin-2-yl]-N-(1-methyl-1H-benzoimidazol-2-ylmethyl)-2-phenyl-acetamide 

Relevant articles and documents

1-METHYL-2-BENZIMIDAZOLYLCARBENE. REACTION OF 1-METHYL-2-(CHLOROMETHYL)BENZIMIDAZOLE WITH NUCLEOPHILES

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CHEMICAL COMPOUNDS AS ANTIBIOTICS

The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p? q, L, ?, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

BENZIMIDAZOLE COMPOUNDS THAT ARE VITRONECTIN RECEPTOR ANTAGONISTS

The present invention provides compounds having formula (I) wherein n, p, q and r are each independently selected from 0 or 1; a, b, c, and d each independently represents a carbon or nitrogen atom, with the proviso that no more than two of a, b, c, and d are nitrogen atoms; Y and Y' each independently represents 1-4 optional substituents selected from alkyl, alkoxy, halo, -CF3, and -C(O)OH; R, R, R and R are H or specified substituents; R, R, R, R, R, R, R and R are independently selected from H or C1-C3 alkyl; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. Also provided are methods of using these compounds for treating vitronectin-mediated disorders, e.g., cancer, retinopathy, artherosclerosis, vascular restenosis, and osteoporosis.