200282-97-9

Upstream product

• 290354-73-3 (3S,4R,5R)-5-(tert-butyldiphenylsilyloxymethyl)-3,4-dihydroxypyrrolidin-2-one 
• 290354-71-1 (2'S,3'R,4S,4'R)-4-Benzyl-3-[2'-benzyloxy-5'-(tert-butyldiphenylsiloxy)-4'-dibenzylamino-3'-hydroxypentanoyl]oxazolidin-2-one 
• 290354-72-2 (2S,3R,4R)-2-Benzyloxy-5-(tert-butyldiphenylsiloxy)-4-dibenzylamino-3-hydroxy-N-methoxy-N-methylpentanamide 
• 290354-67-5 Methyl (2R)-3-(tert-butyldiphenylsiloxy)-2-(dibenzylamino)propanoate 
• 290354-68-6 (2S)-3-tert-butyldiphenylsilyloxy-2-(N,N-dibenzylamino)propan-1-ol 
• 290354-66-4 (2S)-3-(tert-Butyldiphenylsiloxy)-2-(dibenzylamino)propanal 

Relevant academic research and scientific papers

A flexible and efficient synthesis of the pyrrolidine α-glycosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol (DAB-1)

The synthesis of the pyrrolidine α-glycosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol (DAB-1) was discussed. The synthesis used serine-derived α-dibenzylamino aldehyde in a highly diastereoselective glycolate aldol reaction. The glycolate derivative of Evans' oxazolidinone compound was found to be prepared using benzyl-oxyacetyl chloride and 4-benzyloxazolidin-2-one. The analysis showed that the deprotection of the N-benzyl protecting groups was completed within the first 2-3 h of the reaction.