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GNE140 is a selective and potent small molecule inhibitor of the protein sialyltransferase, an enzyme involved in the biosynthesis of sialic acids. Sialic acids are important components of cell surface glycoproteins and glycolipids, playing a crucial role in cell signaling and adhesion. By inhibiting sialyltransferase, GNE140 can disrupt the normal function of sialic acids, potentially leading to downstream effects on cell signaling pathways, cell adhesion, and immune responses. It has shown promise as a potential therapeutic agent for the treatment of cancer and inflammatory diseases, with ongoing research exploring its potential applications in various medical conditions.

2003234-63-5

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2003234-63-5 Usage

Uses

Used in Cancer Treatment:
GNE140 is used as a therapeutic agent for the treatment of cancer, as it can disrupt the normal function of sialic acids, potentially leading to downstream effects on cell signaling pathways and cell adhesion. This disruption may help in inhibiting tumor growth and progression.
Used in Inflammatory Disease Treatment:
GNE140 is used as a therapeutic agent for the treatment of inflammatory diseases, as its inhibition of sialyltransferase can potentially modulate immune responses and reduce inflammation.
Used in Pharmaceutical Industry:
GNE140 is used as a research compound for the development of new drugs targeting sialyltransferase, with potential applications in various medical conditions related to cell signaling, cell adhesion, and immune responses.

Check Digit Verification of cas no

The CAS Registry Mumber 2003234-63-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,0,3,2,3 and 4 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 2003234-63:
(9*2)+(8*0)+(7*0)+(6*3)+(5*2)+(4*3)+(3*4)+(2*6)+(1*3)=85
85 % 10 = 5
So 2003234-63-5 is a valid CAS Registry Number.

2003234-63-5Upstream product

2003234-63-5Downstream Products

2003234-63-5Relevant academic research and scientific papers

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

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Page/Page column 79-80; 233, (2015/11/10)

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

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