20033-00-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzimidazoleethanol,5-chloro-(8CI) is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a valuable component in the development of new drugs and medications.
Used in Antiparasitic Applications:
Due to its structural properties, 2-Benzimidazoleethanol,5-chloro-(8CI) may have potential applications as an antiparasitic agent. It could be used to develop treatments for various parasitic infections, offering a new approach to combating these diseases.
Used in Antimicrobial Applications:
Similarly, 2-Benzimidazoleethanol,5-chloro-(8CI) may also have potential as an antimicrobial agent. Its unique structure could contribute to the development of new antibiotics or antimicrobial compounds, helping to address the growing issue of antibiotic resistance.

InChI:InChI=1/C9H9ClN2O/c10-6-1-2-7-8(5-6)12-9(11-7)3-4-13/h1-2,5,13H,3-4H2,(H,11,12)

Upstream product

• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 109-78-4 3-Hydroxypropionitrile 

Relevant academic research and scientific papers

4-Isopropylchroman-3-ol derivatives

The present invention relates to a novel 4-isopropylchroman-3-ol compound, a pharmaceutical composition comprising the novel compound as an effective component, and to an intermediate compound useful for synthesizing the compound. When administered to a patient with a drug causing toxicity, the novel 4-isopropylchroman-3-ol compound exhibits efficacy of reducing toxicity of the drug by reducing antagonism regarding a T-type calcium channel and/or activity of cytochrome P450 isozyme.

Efficient synthesis of mibefradil analogues: An insight into in vitro stability

This article describes the synthesis and biological evaluation of a chemical library of mibefradil analogues to investigate the effect of structural modification on in vitro stability. The construction of the dihydrobenzopyran structure in mibefradil derivatives 2 was achieved through two efficient approaches based on a diastereoselective intermolecular Reformatsky reaction and an intramolecular carbonyl-ene cyclization. In particular, the second strategy through the intramolecular carbonyl-ene reaction led to the formation of a key intermediate 3 in a short and highly stereoselective way, which has allowed for practical and convenient preparation of analogues 2. Using this protocol, we could obtain 22 new mibefradil analogues 2, which were biologically tested for in vitro efficacies against T-type calcium channels and metabolic stabilities. Among the synthesized compounds, we found that analogue 2aa containing a dihydrobenzopyran ring and a secondary amine linker showed high % remaining activities of the tested CYP enzymes retaining the excellent T-type calcium channel blocking activity. These findings indicated that the structural modification of 1 was effective for improving in vitro stability, i.e., reducing CYP inhibition and metabolic degradation. the Partner Organisations 2014.