200335-68-8

Basic information

• Product Name: PERICOSINE A
• Synonyms: PERICOSINE A
• CAS NO: 200335-68-8
• Molecular Formula: C₈H₁₁ClO₅
• Molecular Weight: 222.62
• Product Categories: Antibiotic
• Mol File: 200335-68-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• PKA: 12.77±0.70(Predicted)
• CAS DataBase Reference: PERICOSINE A(CAS DataBase Reference)
• NIST Chemistry Reference: PERICOSINE A(200335-68-8)
• EPA Substance Registry System: PERICOSINE A(200335-68-8)

Safety Data

• Hazardous Substances Data: 200335-68-8(Hazardous Substances Data)

Upstream product

• 1345470-74-7 C₁₈H₃₄O₄Si 
• 1345470-78-1 (3aR,4R,5R,7aS)-methyl 4,5-dihydroxy-3a,4,5,7a-tetrahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-6-carboxylate 
• 1345470-77-0 (3aS,4R,5R,7aS)-methyl 5-hydroxy-4-(methoxymethoxy)-3a,4,5,7a-tetrahydrospiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-6-carboxylate 
• 1345470-75-8 (3R,4R)-methyl 3-hydroxy-4-(methoxymethoxy)-2-methylene-4-((2S,3S)-3-vinyl-1,4-dioxaspiro[4.5]decan-2-yl)butanoate 
• 1345470-76-9 C₁₄H₂₂O₅ 
• 902134-14-9 (R)-1-((2R,3S)-3-vinyl-1,4-dioxaspiro[4,5]decan-2-yl)ethane-1,2-diol 
• 1227264-30-3 methyl (3aS,6S,7S,7aS)-7-(acetyloxy)-6-chloro-2,2-dimethyl-3a,6,7,7a-tetrahydro-1,3-benzodioxole-5-carboxylate 
• 1163681-01-3 methyl (3S,4R,5S,6S)-6-chloro-3,4-O-cyclohexylidene-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate 
• 949159-78-8 methyl (3S,4S,5R)-5-O-tert-butyldimethylsilyl-3,4-O-cyclohexylidene-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate 
• 168961-19-1 methyl (3S,4R,5R)-3,4-O-cyclohexylidene-3,4,5-trihydroxy-1-cyclohexene-1-carboxylate 
• 949159-86-8 methyl (3R,4S,5S,6R)-3-O-tert-butyldimethylsilyl-4,5-O-cyclohexylidene-3,4,5,6-tetrahydroxy-1-cyclohexene-1-carboxylate 
• 949159-85-7 methyl (3R,4S,SR,6R)-6-O-acetyl-3-O-tert-butyldimethylsilyl-4,5-O-cyclohexylidene-3,4,5,6-tetrahydroxy-1-cyclohexene-1-carboxylate 
• 949159-84-6 methyl (3R,4R,5S,6R)-6-O-acetyl-4,5-O-cyclohexylidene-3,4,5,6-tetrahydroxy-1-cyclohexene-1-carboxylate 
• 949159-83-5 methyl (4S,5S,6R)-6-O-acetyl-4,5-O-cyclohexylidene-4,5,6-trihydroxy-3-oxo-1-cyclohexene-1-carboxylate 

Downstream Products

• 1002731-38-5 methyl (3R,4R,5R,6R)-3,4,5-trihydroxy-6-methoxy-1-cyclohexene-1-carboxylate 

Relevant articles and documents

Facile carbohydrate-based stereocontrolled divergent synthesis of (+)-pericosines A and B

An isomer-divergent synthesis of naturally occurring pericosines A and B is described starting from a known d-ribose derived ene-diol in 35% and 41% overall yields respectively of which the latter is the best synthetic method reported for pericosine B. Th

Chemoenzymatic synthesis of carbasugars (+)-pericosines A-C from diverse aromatic cis-dihydrodiol precursors

cis-Dihydrocatechols, derived from biological cis-dihydroxylation of methyl benzoate, iodobenzene and benzonitrile, using the microorganism Pseudomonas putida UV4, were converted into pericosines A, C, and B, respectively. This approach constitutes the shortest syntheses, to date, of these important natural products with densely packed functionalities.

First total synthesis of antitumor natural product (+)- and (-)-pericosine A: Determination of absolute stereo structure

(Chemical Equation Presented) The first total synthesis of (+)- and (-)-pericosine A has been achieved, enabling the revision and determination of the absolute configuration of this antitumor natural product as methyl (3S,4S,5S,6S)-6-chloro-3,4,5-trihydro