200355-07-3Relevant academic research and scientific papers
Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols
Gaspar, Francisco V.,Barcellos, Julio C.F.,Cívicos, José F.,Merino, Pedro,Nájera, Carmen,Costa, Paulo R.R.
, (2020)
The oxyarylation of alkoxy-2H-chromenes (1a-e) with o-iodophenols substituted by electron-withdrawing (CHO) and electron-donating (OMe) groups is studied under two experimental conditions: a) Pd(OAc)2, Ag2CO3 in PEG-400 at 140 °C, 10 min and b) oxime-based palladacycle, DIPEA, in PEG-400 at 150 °C, 3–4 h. Pterocarpans are obtained in moderate to good chemical yields.
A conceptually novel construction of the 6a-hydroxypterocarpan skeleton – Synthesis of (±)-variabilin
Ciesielski, Philipp,Metz, Peter
, p. 6175 - 6177 (2017)
A new access to the 6a-hydroxypterocarpan variabilin was established. Key step of this concise total synthesis is a challenging cyclization of a haloketone via halogen–metal exchange and subsequent intramolecular addition to the carbonyl function.
