20041-97-8Relevant academic research and scientific papers
Inexpensive Radical Methylation and Related Alkylations of Heteroarenes
Huang, Qi,Zard, Samir Z.
, p. 1413 - 1416 (2018)
A simple method for the introduction of a methyl and higher aliphatic group to various heteroarenes using very inexpensive reagents is described. It is based on the radical addition of a carboxylic xanthate followed by decarboxylation. Depending on the heteroarene structure, the decarboxylation can be spontaneous or induced by heating in N,N-dimethylacetamide or N-methyl pyrrolidone in a microwave oven.
