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200421-03-0

Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester

    Cas No: 200421-03-0

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  • 200421-03-0 Structure

  • Basic information

    1. Product Name: Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester
    2. Synonyms: Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester
    3. CAS NO:200421-03-0
    4. Molecular Formula:
    5. Molecular Weight: 315.369
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 200421-03-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester(200421-03-0)
    11. EPA Substance Registry System: Hydroxy-[2-oxo-4-(4-phenyl-but-3-ynyl)-azetidin-1-yl]-acetic acid isopropyl ester(200421-03-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 200421-03-0(Hazardous Substances Data)

200421-03-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 200421-03-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,4,2 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 200421-03:
(8*2)+(7*0)+(6*0)+(5*4)+(4*2)+(3*1)+(2*0)+(1*3)=50
50 % 10 = 0
So 200421-03-0 is a valid CAS Registry Number.

200421-03-0Relevant articles and documents

Halide-terminated N-acyliminium ion-alkyne cyclizations: A new construction of carbacephem antibiotics

Metais, Eric,Overman, Larry E.,Rodriguez, Maria Ines,Stearns, Brian A.

, p. 9210 - 9216 (2007/10/03)

A series of 4-(3-alkynyl)azetidinones 13 was prepared from 4- (phenylsulfonyl)azetidine-2-one (9) and isopropyl glyoxylate hydrate. The 3- pentynyl (13a) and 4-phenyl-3-butynyl (13b) azetidinone acetates underwent 6- exo cyclization when treated with 3 equity of SnCl4 at 0 °C to provide 3- (1-chloroalkylidene)carbacephems 15a (65%) and 15b (33%) respectively. In contrast, the 3-butynyl (13d) and 4-(trimethylsilyl)-3-butynyl (13c) azetidinone acetates underwent 7-endo cyclization under similar conditions to give 1-azabicyclo[5.2.0]nonenes 14a (11%) and 14b (71%), respectively. Beginning with penicillin degradation product 18, the more elaborate 3- pentynyl azetidinone cyclization substrate 27 was prepared in seven steps. Exposure to 27 to 3 equiv of SnCl4 in CH2Cl2 at 0 °C for 6 h, followed by allowing the reaction mixture to warm to rt, provided the desired 3-(1- chloroethylidene)carbacephem 28 in 60% yield and high (>99%) enantiometric purity. Cleavage of the chloroethylidene group of 28 with ozone gave 3- hydroxy carbacephem 29 in 77% yield. Since this intermediate has been converted in three steps to loracarbef (3), a new formal total synthesis of this carbacephem antibiotic was concluded.

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