200421-52-9

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 126-81-8 dimedone 

Downstream Products

• 40588-50-9 3,3,6,6-tetramethyl-9-(3-nitrophenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione 

Relevant academic research and scientific papers

A four-ketone derivative and its preparation method and application

The invention provides tetrone derivatives as well as a preparation method and application thereof. The derivatives have a general formula structure shown in the specification, wherein in the structure, R1 is any one of -H, 4-OCH3, 2-Cl, 3,4-(OCH3)2, 4-CH

Merging supramolecular catalysis and aminocatalysis: Amino-appended β-cyclodextrins (ACDs) as efficient and recyclable supramolecular catalysts for the synthesis of tetraketones

Well-designed amino-appended β-cyclodextrins (ACDs) with an amino side chain of different lengths at the primary face of β-CD were synthesized and employed in the catalytic synthesis of a series of tetraketones as supramolecular catalysts in water for the first time. Yields of 58-97% were obtained with up to 30 examples of substrate. The catalyst could be recycled easily, while a 92% yield and 84% rate of catalyst recovery could be achieved after 8 cycles of catalyst recycling. Moreover, a catalytic mechanism merging supramolecular catalysis and aminocatalysis could be proposed through detailed 1D and 2D NMR, ESI-MS and Job plot analyses. This protocol retained the promising characteristics of ambient temperature, green medium, simple operation, broad substrate scope, excellent yields, superb catalyst recycling performance and unique catalytic mechanism.

L-Proline-catalysed the synthesis of aromatic aldehydes and ketones and their acridione derivatives at room temperature

A series of xanthene derivatives were prepared from cyclohexane-1,3-dione and aromatic aldehydes through Knoevenagel-Michael and cyclisation reactions in methanol:ethanol mixture (1:1), catalysed by a very small amount of l-proline at room temperature. Is

A green and highly efficient protocol for catalyst-free Knoevenagel condensation and Michael addition of aromatic aldehydes with 1,3-cyclic diketones in PEG-400

A convenient, highly efficient and green approach for synthesis of tetraketones from aromatic aldehydes with dimedone and 1,3-indanedione at room temperature in PEG-400 is described. The use of PEG-400 as the reaction medium and avoiding the use of any ca

An efficient and simple synthesis of tetraketones catalyzed by Yb(OTf) 3-sio2 under solvent free conditions

A novel and efficient three-component one-pot condensation method has been described for the synthesis of tetraketones or arylmethylene[bis(3-hydroxy-2- cyclohexene-1-ones)] using Yb(OTf)3-SiO2 and amine as catalytic system under sol

Tetraketones: A new class of tyrosinase inhibitors

Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC50 = 2.06 μM), 11 (IC50 = 2.09 μM), 15 (IC 50 = 2.61 μM), and 27 (ICsu