200422-61-3Relevant academic research and scientific papers
Synthesis and antiprotozoan properties of new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives
Ochoa, Carmen,Perez, Eduardo,Perez, Roland,Suarez, Margarita,Ochoa, Estael,Rodriguez, Hortensia,Gomez Barrio, Alicia,Muclas, Susana,Jose Nogal, Juan,Martinez, Rafael A.
, p. 764 - 769 (2007/10/03)
In a search for antiprotozoan compounds, 34 new 3,5-disubstituted- tetrahydro-2H-1,3,5-thiadiazine-2-thione derivatives were synthesized and tested in vitro against Trypanosoma cruzi and Trichomonas vaginalis. Some of them showed important antiprotozoan a
New carriers for representative peptides and peptide drugs
Aboul-Fadl, Tarek,El-Shorbagi, Abdel-Nasser
, p. 327 - 332 (2007/10/03)
3,5-Disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivatives; 4a-g were prepared and found to be a promising prodrug approach for peptide drugs. The pH profile for their degradation in aqueous buffer solutions was determined using HPLC technique and accounted for, in terms of specific base-catalyzed reactions. All of the compounds however, showed high acid-stability. Enzymatic (human serum) hydrolysis of the different derivatives offered an advantageous range of t( 1/4 )'s, the property that permits controlling onset and duration of actions of drugs.
