200423-21-8

Upstream product

• 110-89-4 piperidine 
• 157069-50-6 4-chloro-3-(methylsulfonyl)benzoic acid methyl ester 
• 51522-07-7 3-methylsulphonyl-4-chlorobenzoic acid 
• 135051-09-1 3-methylsulfonyl-4-(1-piperidino)benzoic acid 

Downstream Products

• 149725-39-3 (3-methylsulfonyl-4-piperidylbenzoyl)-(aminoiminomethyl)amine 
• 149725-40-6 N-(3-Methanesulfonyl-4-piperidin-1-yl-benzoyl)-guanidine; compound with methanesulfonic acid 

Relevant academic research and scientific papers

Synthesis of the highly selective Na+/H+ exchange inhibitors cariporide mesilate and (3-methanesulfonyl-4-piperidino-benzoyl) guanidine methanesulfonate

The syntheses of cariporide mesilate ((4-isopropyl-3-methanesulfonyl-benzoyl) guanidine methanesulfonate, HOE 642, CAS 159138-81-5), currently being clinically investigated as a protective drug in cardiac ischemia and reperfusion states, and of HOE 694 ((3-methanesulfonyl-4-piperidino-benzoyl)guanidine methanesulfonate, CAS 149725-40-6), widely used as a physiological and pharmacological research tool in studies comprising Na+/H+ exchange (NHE) inhibition, are described. Additionally, their selectivity on the different subtypes is disclosed.