200440-13-7Relevant articles and documents
Synthesis of thiazole analogues of the immunosuppressive agent (1R,25,3A)-2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole
Jeoffreys, George R.,Ung, Alison T.,Pyne, Stephen G.,Skelton, Brian W.,White, Allan H.
, p. 2281 - 2291 (1999)
The synthesis of four of the diastereoisomers of 2-acetyl-5-(l ,2,3,4-tetrahydroxybutyl)thiazole and two of the diastereoisomers of 2-acetyl-5-( 1,2,3,4,5-pentahydroxypentyl)thiazole and 2-acetyl-4-( 1,2,3,4,5-pentahydroxypentyl)thiazole are reported. These syntheses involve the condensation of 5- or 4-metallated 2-( 1,1 -dimethoxyethyl)thiazoles with 2,3-O-isopropylidene-D-erythrono-l,4-lactone or 5-O-(tert-butyldimethylsilyl)-2,3-O-isopropylideneD-ribonolactone followed by reductive ring-opening of the resulting lactols. The stereochemistries and structures of some key compounds have been determined by single crystal X-ray structural analysis.
NLRP3 INHIBITORS
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Page/Page column 74, (2020/06/10)
The present application relates to compounds with NLRP3inhibitory activity and to associated salts, solvates, prodrugs and pharmaceutical compositions. The present application further relates to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3inhibition.
FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Paragraph 0298; 0299, (2015/12/08)
no abstract published