20057-39-0

Usage

Uses

Used in Detergent Production:
(nonyloxy)acetic acid is utilized as a surfactant in the manufacturing of detergents, enhancing their cleaning capabilities by reducing the surface tension of water, allowing it to mix with oil and dirt, and facilitating their removal.
Used in Industrial and Household Cleaning Products:
Due to its surfactant properties, (nonyloxy)acetic acid is employed in various cleaning products for both industrial and household use, improving their effectiveness in cleaning and degreasing.
Used in Personal Care Products and Cosmetics:
In the personal care and cosmetics industry, (nonyloxy)acetic acid serves as an emulsifying agent, playing a crucial role in the formulation of products by helping to stabilize and disperse insoluble substances within a liquid medium, thus ensuring a uniform and consistent texture.
Used in Manufacturing Processes:
The surfactant and emulsifying properties of (nonyloxy)acetic acid make it a common ingredient in the production of various products that require the stabilization and dispersion of insoluble substances, such as in the pharmaceutical, food, and chemical industries.

Upstream product

• 79-11-8 chloroacetic acid 
• 143-08-8 nonyl alcohol 
• 305-53-3 monosodium iodoacetate 

Relevant academic research and scientific papers

Development of small-molecule inhibitors of fatty acyl-AMP and fatty acyl-CoA ligases in Mycobacterium tuberculosis

Lipid metabolism in Mycobacterium tuberculosis (Mtb) relies on 34 fatty acid adenylating enzymes (FadDs) that can be grouped into two classes: fatty acyl-CoA ligases (FACLs) involved in lipid and cholesterol catabolism and long chain fatty acyl-AMP ligases (FAALs) involved in biosynthesis of the numerous essential and virulence-conferring lipids found in Mtb. The precise biochemical roles of many FACLs remain poorly characterized while the functionally non-redundant FAALs are much better understood. Here we describe the systematic investigation of 5′-O-[N-(alkanoyl)sulfamoyl]adenosine (alkanoyl adenosine monosulfamate, alkanoyl-AMS) analogs as potential multitarget FadD inhibitors for their antitubercular activity and biochemical selectivity towards representative FAAL and FACL enzymes. We identified several potent compounds including 12-azidododecanoyl-AMS 28, 11-phenoxyundecanoyl-AMS 32, and nonyloxyacetyl-AMS 36 with minimum inhibitory concentrations (MICs) against M. tuberculosis ranging from 0.098 to 3.13 μM. Compound 32 was notable for its impressive biochemical selectivity against FAAL28 (apparent Ki = 0.7 μM) versus FACL19 (Ki > 100 μM), and uniform activity against a panel of multidrug and extensively drug-resistant TB strains with MICs ranging from 3.13 to 12.5 μM in minimal (GAST) and rich (7H9) media. The SAR analysis provided valuable insights for further optimization of 32 and also identified limitations to overcome.

INHIBITORS OF BIOFILM FORMATION OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA

The present invention relates to the use of compounds as broad spectrum inhibitors of bacterial biofilm formation. In particular the invention refers to a family of compounds that block the quorum sensing system of Gram-negative and Gram-positive bacteria, a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of bacterial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.

Antifungal properties of n-alkoxyacetic acids and their methyl esters

Eleven n-alkoxyacetic acids and their methyl esters, in which the alkyl group was C1-C9, C11, or C13, were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 4.0 and 5.6. Toxicity to Candida albicans, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. The fungitoxicity of the acids was influenced by chain length, pH of the medium, and absence or presence of adsorbents. The toxicity of the esters was influenced primarily by chain length and to a lesser extent by the medium pH and the presence of beef serum. The order of activity of the n-alkoxyacetic acids was according to the number of linear atoms in the chain: 11>12>10>9>8>7>6>14>16. T. mentagrophytes was the organism most strongly affected by these compounds, with the esters being slightly more active than the acids. Compared to other fatty acid analogs, the order of fungitoxicity, on a weight basis, was 2-alkynoic acids >2-alkenoic acids > alkanoic acids > 2-bromoalkanoic acid > 2-fluoroalkanoic acids > n-alkoxyacetic acids.