20057-56-1Relevant articles and documents
Targeting synthetic analogues of the metallo-sulfur active sites of nickel enzymes capable of important catalysis
Smith, Matt C.,Barclay, J. Elaine,Davies, Sian C.,Hughes, David L.,Evans, David J.
, p. 4147 - 4151 (2007/10/03)
The nickel containing enzymes NiFe-hydrogenase, carbon monoxide dehydrogenase and acetyl-CoA synthase are able to catalyse environmentally, and potentially industrially, important reactions: hydrogen uptake; carbon dioxide/carbon monoxide interconversion; and incorporation of carbon monoxide to form acetyl-CoA, respectively. Progress toward the synthesis of nickel-iron complexes with structural features related to the active sites of these enzymes are described, together with the synthesis, properties and crystal structure of the first methylated-nickel-iron diheterometallic complex, [{Fe(NS3)(NO)-S} Ni(CH3)(dppe)] (NS3 = N(CH2CH2S)33-), relevant to a proposed mechanistic intermediate in the acetyl-CoA synthase mechanism.
