20062-91-3

Basic information

• Product Name: 3-(4-Phenoxyphenyl)propionic acid
• Synonyms: 4-Phenoxybenzenepropanoic acid
• CAS NO: 20062-91-3
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.28
• Mol File: 20062-91-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 393.921°C at 760 mmHg
• Flash Point: 147.415°C
• Appearance: /
• Density: 1.188g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-Phenoxyphenyl)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Phenoxyphenyl)propionic acid(20062-91-3)
• EPA Substance Registry System: 3-(4-Phenoxyphenyl)propionic acid(20062-91-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 20062-91-3(Hazardous Substances Data)

Usage

General Description

3-(4-Phenoxyphenyl)propionic acid is a chemical compound that belongs to the class of propionic acids. Its molecular structure consists of a propionic acid molecule attached to a 4-phenoxyphenyl group. 3-(4-Phenoxyphenyl)propionic acid is often used as a nonsteroidal anti-inflammatory drug (NSAID) due to its ability to reduce pain and inflammation. It is commonly prescribed for the treatment of conditions such as rheumatoid arthritis, osteoarthritis, and menstrual pain. Additionally, 3-(4-Phenoxyphenyl)propionic acid has been studied for its potential anti-cancer properties, as well as its ability to inhibit the growth of certain types of cancer cells. Overall, this chemical compound has shown promise in various therapeutic applications due to its anti-inflammatory and potential anti-cancer effects.

InChI:InChI=1/C15H14O3/c16-15(17)11-8-12-6-9-14(10-7-12)18-13-4-2-1-3-5-13/h1-7,9-10H,8,11H2,(H,16,17)

Upstream product

• 861856-61-3 ethyl 3-(4-phenoxyphenyl)propanoate 
• 945414-28-8 ethyl (E)-3-(4-phenoxyphenyl)acrylate 
• 67-36-7 4-phenoxy benzaldehyde 
• 185051-02-9 methyl 3-(4-phenoxyphenyl)propanoate 

Relevant articles and documents

BODIPY-based fluorescent probe for peroxynitrite detection and imaging in living cells

A fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO-). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-γ (IFN-γ), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.2009 American Chemical Society.

Structure-activity relationships of α-ketooxazole inhibitors of fatty acid amide hydrolase

A systematic study of the structure-activity relationships of 2b (OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed targeting the C2 acyl side chain. A series of aryl replacements or substituents for the terminal phenyl group provided effective inhibitors (e.g., 5c, aryl = 1-napthyl, K, - 2.6 nM), with 5hh (aryl -3-ClPh, Ki = 900 pM) being 5-fold more potent than 2b. Conformationally restricted C2 side chains were examined, and many provided exceptionally potent inhibitors, of which 11j (ethylbiphenyl side chain) was established to be a 750 pM inhibitor. A systematic series of heteroatoms (O, NMe, S), electron-withdrawing groups (SO, SO2), and amides positioned within and hydroxyl substitutions on the linking side chain were investigated, which typically led to a loss in potency. The most tolerant positions provided effective inhibitors (12p, 6-position S, Ki = 3 nM, or 13d, 2-position OH, Ki = 8 nM) comparable in potency to 2b. Proteome-wide screening of selected inhibitors from the systematic series of >100 candidates prepared revealed that they are selective for FAAH over all other mammalian serine proteases.