20063-73-4Relevant academic research and scientific papers
Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis- bioreductive agent nitracrine N-oxide
Lee,Wilson,Ferry,Van Zijl,Pullen,Denny
, p. 2508 - 2517 (1996)
A series of nuclear-substituted derivatives of nitracrine N-oxide (2; a bis-bioreductive hypoxia-selective cytotoxin) were prepared and evaluated, seeking analogues of lower nitroacridine reduction potential. Disubstitution with Me or OMe groups at the 4-
