200642-84-8Relevant articles and documents
Enantiopure β3-neopentylglycine: synthesis and resolution
ter Wiel, Matthijs K.J.,Arnold, Mirjam,Peter, Sandra,Troltsch, Ingo,Merget, Stefan,Glaser, Florian,Schwarm, Michael,Bhatti, Harjinder S.,Kuriakose, Biju,Pol, Suryakant S.,Balamurugan, Mohanasundaram,Joshi, Viral V.
experimental part, p. 478 - 482 (2009/09/08)
A procedure has been developed for the large scale synthesis of enantiopure β3-neopentylglycine and its Cbz-protected derivative. The synthetic route developed in our laboratory features Cbz-protection of the racemic β-amino acid followed by resolution with l-norephedrine and provides the enantiomerically pure Cbz-β-neopentylglycine in good yield and excellent enantiopurity. No toxic or dangerous chemicals are used, allowing the scale-up of this procedure without major safety concerns.
