20069-02-7

Basic information

• Product Name: 1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-β-carboline
• Synonyms: (-)-1-Methyl-4-[(2S)-1-methyl-2-pyrrolidinyl]-9H-pyrido[3,4-b]indole;(-)-Brevicolline;(S)-Brevicolline;1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-9H-pyrido[3,4-b]indole;1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-β-carboline;Brevicolline
• CAS NO: 20069-02-7
• Molecular Formula: C17H19N3
• Molecular Weight: 265.35286
• Mol File: 20069-02-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 459.4°C at 760 mmHg
• Flash Point: 231.6°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 1.27E-08mmHg at 25°C
• Refractive Index: 1.691
• CAS DataBase Reference: 1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-β-carboline(20069-02-7)
• EPA Substance Registry System: 1-Methyl-4-[(2S)-1-methyl-2α-pyrrolidinyl]-β-carboline(20069-02-7)

Safety Data

• Hazardous Substances Data: 20069-02-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H19N3/c1-11-17-16(12-6-3-4-7-14(12)19-17)13(10-18-11)15-8-5-9-20(15)2/h3-4,6-7,10,15,19H,5,8-9H2,1-2H3

Upstream product

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Relevant articles and documents

Synthesis of enantiomerically pure (-)-(S)-brevicolline

(-)-(S)-Brevicolline (1) and related β-carbolines were synthesized using an enantiomerically pure Michael-acceptor synthon (3). Subsequent Pictet-Spengler reaction afforded the tetrahydro-β-carboline skeleton, which, in turn, was transformed to the β-carboline by catalytic dehydrogenation.

SYNTHESIS AND REGIOSELECTIVE SUBSTITUTION OF 6-HALO-AND 6-ALKOXY NICOTINE DERIVATIVES

The present invention provides active compounds for modulating nicotinic acetylcholine receptors and methods of making the same. The methods of preparing the active compounds utilize different intermediate compounds.