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2007-07-0

2-Hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide is a complex organic compound with the molecular formula C18H20NO4+.I-. It is a derivative of isoquinoline, a heterocyclic aromatic compound with a benzene ring fused to a pyridine ring. The molecule features a hydroxyl group at the 2-position, three methoxy groups at the 3, 9, and 10 positions, and a dihydroisoquinolinium cation. The iodide anion is present as a counterion, forming an ionic compound. 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide is known for its potential applications in the field of organic chemistry, particularly in the synthesis of various pharmaceuticals and natural products. Its structure and properties make it an interesting target for further research and development in the realm of chemical synthesis and drug discovery.

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  • 2007-07-0 Structure

  • Basic information

    1. Product Name: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide
    2. Synonyms: 5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium iodide; Columbamine iodide
    3. CAS NO:2007-07-0
    4. Molecular Formula: C20H20NO4*I
    5. Molecular Weight: 465.2816
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 2007-07-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide(2007-07-0)
    11. EPA Substance Registry System: 2-hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium iodide(2007-07-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2007-07-0(Hazardous Substances Data)

2007-07-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2007-07-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,0 and 7 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2007-07:
(6*2)+(5*0)+(4*0)+(3*7)+(2*0)+(1*7)=40
40 % 10 = 0
So 2007-07-0 is a valid CAS Registry Number.

2007-07-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-hydroxy-3-methoxy-9,10-dimethoxyprotoberberine iodide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2007-07-0 SDS

2007-07-0Upstream product

2007-07-0Downstream Products

2007-07-0Relevant articles and documents

Berberine analogues as a novel class of the low-density-lipoprotein receptor up-regulators: Synthesis, structure-activity relationships, and cholesterol-lowering efficacy

Li, Ying-Hong,Yang, Peng,Kong, Wei-Jia,Wang, Yan-Xiang,Hu, Chang-Qin,Zuo, Zeng-Yan,Wang, Yue-Ming,Gao, Hong,Gao, Li-Mei,Feng, Yan-Chun,Du, Na-Na,Liu, Ying,Song, Dan-Qing,Jiang, Jian-Dong

experimental part, p. 492 - 501 (2009/09/25)

Twenty-nine derivatives of berberine (1) or pseudoberberine (2) were designed, semisynthesized, and evaluated for their up-regulatory activity on the low-density-lipoprotein receptor (LDLR) expression. SAR analysis revealed that (i) the methylenedioxy group at the 2- and 3-position is an essential element to keep the activity, (ii) the 7-position quaternary ammonium and planar structure of the compound are activity-required, and (iii) addition of electron-donating groups at the 7- or 13-position reduced the activity. Of the compound 1 analogues, compound 2 exhibited an increased activity on LDLR expression compared to 1.Inthe hyperlipidemic rats, compound 2 (100 (mg/kg)/day) reduced blood CHO and LDL-c by 42.6% and 49.4%, respectively, more efficient than 1 did (p 50 of 2 in mice was over 5000 mg/kg (oral). We consider compound 2 a promising cholesterol- lowering drug candidate.

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