200708-50-5Relevant academic research and scientific papers
Fused aminotetralins: Novel antagonists with high selectivity for the dopamine D3 receptor
Avenell, Kim Y.,Boyfield, Izzy,Coldwell, Martyn C.,Hadley, Michael S.,Healy, Maureen A. M.,Jeffrey, Philip M.,Johnson, Christopher N.,Nash, David J.,Riley, Graham J.,Scott, Emma E.,Smith, Stephen A.,Stacey, Rachel,Stemp, Geoffrey,Thewlis, Kevin M.
, p. 2859 - 2864 (1998)
Starting from a series of 2-aminotetralins 1, a novel series of N-[4- (4-phenylbenzoylamino)butyl]-octahydrobenzoquinolines and hexahydrobenzoindoles with high potency and selectivity for the dopamine D3 receptor has been designed. The effect of ligand chirality on binding affinity has been established. Selected derivatives (e.g. 2o, 2p) show high functional selectivity and enhanced in vivo properties compared to 1.
Tricyclic amine derivatives
-
, (2008/06/13)
PCT No. PCT/EP97/02985 Sec. 371 Date Dec. 14, 1998 Sec. 102(e) Date Dec. 14, 1998 PCT Filed Jun. 6, 1997 PCT Pub. No. WO97/47602 PCT Pub. Date Dec. 18, 1997A compound of formula (I): wherein R1 represents a group of formula (A) or (B): R2, R3, Ar, Y Ar1 a
